c-Myc Epitope (Myc) Antibody
884€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
c-Myc Epitope (Myc) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx132269
tested applications
WB, DB
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | c-Myc Epitope (Myc) |
| Host | Rabbit |
| Reactivity | General |
| Recommended Dilution | WB: 0.01-2 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, DB |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | MRTL,MYCC,c-Myc,bHLHe39,Transcription factor p64,Proto-oncogene c-Myc,Class E basic helix-loop-helix protein 39 |
| Background | Antibody anti-Myc |
| Status | RUO |
Descripción
The MYC proto-oncogene encodes a basic helix-loop-helix (bHLH) transcription factor that is central to regulating cell growth, proliferation, and metabolism. It acts as a master regulator by binding to E-box sequences within the genome to control the transcription of numerous genes involved in key cellular processes, such as ribosome biogenesis, cell cycle progression, and apoptosis. Dysregulation of MYC, often through overexpression or amplification, is a hallmark of many cancers, including Burkitt lymphoma and various solid tumors. This dysregulation promotes uncontrolled cell proliferation and impairs apoptosis, contributing to tumorigenesis. Additionally, MYC interacts with multiple co-factors and chromatin-modifying complexes, further amplifying its impact on the epigenetic landscape. Given its critical role in oncogenesis, MYC is extensively studied as a therapeutic target, with ongoing efforts to develop strategies to inhibit its activity or downstream pathways to treat MYC-driven malignancies. Its widespread effects on cellular physiology underscore its importance in both normal development and disease.
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