Myc Proto-Oncogene Protein (MYC) Antibody (Biotin)
429€ (0.1 mg)
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Name
Myc Proto-Oncogene Protein (MYC) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx139768
Tested Applications
ELISA, WB, IF/ICC, IP
Description
c-Myc Antibody is a Mouse Monoclonal against c-Myc.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Myc Proto-Oncogene Protein (MYC) Immunogen: Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of Human c-Myc. |
| Host | Mouse |
| Reactivity | General |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Biotin |
| Isotype | IgG1 |
| Clone ID | O971 |
| Size 1 | 0.1 mg |
| Tested Applications | ELISA, WB, IF/ICC, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P01106 |
| Gene ID | 4609 |
| Alias | MRTL,MYCC,c-Myc,bHLHe39,Transcription factor p64,Proto-oncogene c-Myc,Class E basic helix-loop-helix protein 39 |
| Background | Antibody anti-MYC |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The MYC proto-oncogene encodes a basic helix-loop-helix (bHLH) transcription factor that is central to regulating cell growth, proliferation, and metabolism. It acts as a master regulator by binding to E-box sequences within the genome to control the transcription of numerous genes involved in key cellular processes, such as ribosome biogenesis, cell cycle progression, and apoptosis. Dysregulation of MYC, often through overexpression or amplification, is a hallmark of many cancers, including Burkitt lymphoma and various solid tumors. This dysregulation promotes uncontrolled cell proliferation and impairs apoptosis, contributing to tumorigenesis. Additionally, MYC interacts with multiple co-factors and chromatin-modifying complexes, further amplifying its impact on the epigenetic landscape. Given its critical role in oncogenesis, MYC is extensively studied as a therapeutic target, with ongoing efforts to develop strategies to inhibit its activity or downstream pathways to treat MYC-driven malignancies. Its widespread effects on cellular physiology underscore its importance in both normal development and disease.
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