Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Protein

Este producto es parte de MYC proto-oncogene, bHLH transcription factor
Mouse V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein MYC

proveedor

Abbexa

reference

abx069686

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC) is a recombinant Mouse protein produced in a Prokaryotic expression system (E. coli).


Background

The MYC proto-oncogene encodes a basic helix-loop-helix (bHLH) transcription factor that is central to regulating cell growth, proliferation, and metabolism. It acts as a master regulator by binding to E-box sequences within the genome to control the transcription of numerous genes involved in key cellular processes, such as ribosome biogenesis, cell cycle progression, and apoptosis. Dysregulation of MYC, often through overexpression or amplification, is a hallmark of many cancers, including Burkitt lymphoma and various solid tumors. This dysregulation promotes uncontrolled cell proliferation and impairs apoptosis, contributing to tumorigenesis. Additionally, MYC interacts with multiple co-factors and chromatin-modifying complexes, further amplifying its impact on the epigenetic landscape. Given its critical role in oncogenesis, MYC is extensively studied as a therapeutic target, with ongoing efforts to develop strategies to inhibit its activity or downstream pathways to treat MYC-driven malignancies. Its widespread effects on cellular physiology underscore its importance in both normal development and disease.

Características del producto

category

Proteins and Peptides


origin

Mouse


host

E. coli


immunogen target

V-Myc Myelocytomatosis Viral Oncogene Homolog (MYC)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 60.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala186-Ala439 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

MYC


dry ice

No


availability

Shipped within 5-12 working days.


alias

MRTL,MYCC,c-Myc,bHLHe39,Transcription factor p64,Proto-oncogene c-Myc,Class E basic helix-loop-helix protein 39


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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