Family main features
KIRREL, also known as kin of IRRE-like protein or NEPH1, is part of the nephrin-like protein family, which plays a significant role in cell adhesion and signal transduction processes in various tissues. The gene encoding KIRREL is located on chromosome 1q23.1 in humans. KIRREL proteins are characterized by their involvement in the development and maintenance of the slit diaphragm in the kidney's glomerulus, a key structure in the filtration barrier. The importance of KIRREL in maintaining glomerular filtration function highlights its role in kidney health and disease.
KIRREL is a type I transmembrane protein consisting of several distinct domains that contribute to its function:
KIRREL belongs to the nephrin-like protein family, which includes several members with similar structures and functions. This family is part of the larger immunoglobulin superfamily (IgSF), known for its diverse roles in cell adhesion and immune response. Within the nephrin-like protein family, KIRREL can be classified alongside other members such as NEPH2 and NEPH3, each playing specific roles in various tissues.
KIRREL proteins are crucial for maintaining the integrity of the slit diaphragm in kidney glomeruli, which is essential for the filtration of blood. The primary functions and biological significance of KIRREL include:
Mutations or dysregulation of KIRREL can lead to severe clinical conditions, particularly related to kidney function:
KIRREL, or NEPH1, is a key protein in the nephrin-like family, integral to maintaining the filtration barrier in the kidney and playing roles in neural connectivity. Its structure includes extracellular Ig-like domains, a transmembrane segment, and an intracellular domain with signaling motifs, facilitating its functions in cell adhesion and signal transduction. Dysregulation of KIRREL is implicated in severe kidney disorders, such as nephrotic syndrome and FSGS, and potentially in neurological conditions. Understanding KIRREL's roles and mechanisms opens avenues for targeted therapies and improved clinical outcomes in kidney and neurological diseases.
kirre like nephrin family adhesion molecule 1 (KIRREL1)
NEPH1,KIRREL,NPHS23,Nephrin-like protein 1,Kin of irregular chiasm-like protein 1,Kin of IRRE-like protein 1
kirre like nephrin family adhesion molecule 2 (KIRREL2)
NLG1,NEPH3,FILTRIN,Nephrin-like protein 3,Kin of irregular chiasm-like protein 2, Kin of IRRE-like protein 2
kirre like nephrin family adhesion molecule 3 (KIRREL3)
MRD4,KIRRE,NEPH2,PRO4502,Nephrin-like protein 2,Kin of irregular chiasm-like protein 3,Kin of IRRE-like protein 3
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies) relacionados con KIRREL - kirre like nephrin family adhesion molecule
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 19 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | KIRREL2 | abx530042 | Human Kin of IRRE-like protein 2 (KIRREL2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6UWL6 | RUO | ||
Abbexa | KIRREL3 | abx530044 | Human Kin of IRRE-like protein 3 (KIRREL3) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8IZU9 | RUO | ||
Abbexa | KIRREL2 | abx530043 | Mouse Kin of IRRE-like protein 2 (KIRREL2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q7TSU7 | RUO | ||
Abbexa | KIRREL3 | abx530045 | Mouse Kin of IRRE-like protein 3 (KIRREL3) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8BR86 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | KIRREL2 | FNab04590 | anti- KIRREL2 antibody | human | polyclonal | Rabbit | kin of IRRE like 2(Drosophila) | IgG | Unconjugated | ELISA, WB | 100µg | Q6UWL6 | RUO | |
FineTest | KIRREL3 | FNab04591 | anti- KIRREL3 antibody | human | polyclonal | Rabbit | kin of IRRE like 3(Drosophila) | IgG | Unconjugated | ELISA, WB | 100µg | Q8IZU9 | RUO | |
Abbexa | KIRREL2 | abx030480 | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) Antibody | Human | Polyclonal | Rabbit | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q6UWL6 | RUO | |
Abbexa | KIRREL2 | abx212002 | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) Antibody | Human | Polyclonal | Rabbit | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) | Unconjugated | ELISA, WB | 250 | 50 µl | Q6UWL6 | RUO | |
Abbexa | KIRREL2 | abx213458 | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) Antibody | Human | Polyclonal | Rabbit | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) | Unconjugated | ELISA, WB | 250 | 50 µl | Q6UWL6 | RUO | |
Abbexa | KIRREL2 | abx318590 | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) Antibody | Human | Polyclonal | Rabbit | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) | Unconjugated | ELISA, WB | 162.5 | 20 µg | Q6UWL6 | RUO | |
Abbexa | KIRREL2 | abx234590 | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) Antibody | Human | Polyclonal | Rabbit | Kirre Like Nephrin Family Adhesion Molecule 2 (KIRREL2) | Unconjugated | ELISA, WB | 350 | 100 µg | Q6UWL6 | RUO | |
Abbexa | KIRREL3 | abx340767 | Kin of IRRE-like protein 3 (KIRREL3) Antibody | Human | Polyclonal | Rabbit | Kin of IRRE-like protein 3 (KIRREL3) | Unconjugated | ELISA, IF/ICC | 162.5 | 20 µg | Q8IZU9 | RUO | |
Abbexa | KIRREL3 | abx340768 | Kin of IRRE-like protein 3 (KIRREL3) Antibody (HRP) | Human | Polyclonal | Rabbit | Kin of IRRE-like protein 3 (KIRREL3) | HRP | ELISA | 162.5 | 20 µg | Q8IZU9 | RUO | |
Abbexa | KIRREL3 | abx340769 | Kin of IRRE-like protein 3 (KIRREL3) Antibody (FITC) | Human | Polyclonal | Rabbit | Kin of IRRE-like protein 3 (KIRREL3) | FITC | 162.5 | 20 µg | Q8IZU9 | RUO | ||
Abbexa | KIRREL3 | abx340770 | Kin of IRRE-like protein 3 (KIRREL3) Antibody (Biotin) | Human | Polyclonal | Rabbit | Kin of IRRE-like protein 3 (KIRREL3) | Biotin | ELISA | 162.5 | 20 µg | Q8IZU9 | RUO | |
Abbexa | KIRREL3 | abx234591 | Kin of IRRE-Like Protein 3 (KIRREL3) Antibody | Human | Polyclonal | Rabbit | Kin of IRRE-Like Protein 3 (KIRREL3) | Unconjugated | ELISA, WB | 350 | 100 µg | Q8IZU9 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | KIRREL1 | abx692128 | Mouse Kin of IRRE-Like Protein 1 (KIRREL1) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q80W68 | RUO | |
Abbexa | KIRREL3 | abx692402 | Rat Kin Of IRRE-Like Protein 3 (KIRREL3) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q09GS6 | RUO | |
Abbexa | KIRREL3 | abx692481 | Mouse Kin Of IRRE-Like Protein 3 (KIRREL3) Protein | Mouse | Recombinant | HEK293 cells | SDS-PAGE | 962.5 | 100 µg | Q8BR86-1 | RUO |
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