Kin of IRRE-Like Protein 3 (KIRREL3) Antibody
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Description
KIRREL3 Antibody is a Rabbit Polyclonal against KIRREL3.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Kin of IRRE-Like Protein 3 (KIRREL3) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8IZU9 |
| Gene ID | 84623 |
| NCBI Accession | NP_001155179.1, NM_001161707.1, NP_115920.1, NM_032531.3 |
| OMIM | 607761 |
| Alias | MRD4,KIRRE,NEPH2,PRO4502,Nephrin-like protein 2,Kin of irregular chiasm-like protein 3,Kin of IRRE-like protein 3 |
| Background | Antibody anti-KIRREL3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
KIRREL3, also known as nephrin-like protein 3, is expressed predominantly in the nervous system, particularly in neurons. It is involved in synaptic adhesion, axon guidance, and the formation of neural circuits. KIRREL3 plays an essential role in promoting synaptic specificity, enabling proper connectivity between pre- and postsynaptic neurons. Mutations or deletions in KIRREL3 are associated with neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders. KIRREL3 also plays a role in regulating neuronal plasticity and cognitive processes, such as learning and memory. Its dysfunction underscores its significance in maintaining synaptic integrity and neuronal signaling.
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