Mouse Kin of IRRE-Like Protein 1 (KIRREL1) Protein (Active)
1079€ (100 µg)
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935106861
info@markelab.com
name
Mouse Kin of IRRE-Like Protein 1 (KIRREL1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx692128
tested applications
SDS-PAGE
Description
Mouse KIRREL1 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of mouse KIRREL1 (NP_570937.2) (Met 1-Leu 525) was expressed with a C-terminal polyhistidine tag.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | KIRREL1 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 53.8 kDa Sequence Fragment: Met1-Leu525 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 98% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q80W68 |
| NCBI Accession | NP_570937.2 |
| Alias | NEPH1,KIRREL,NPHS23,Nephrin-like protein 1,Kin of irregular chiasm-like protein 1,Kin of IRRE-like protein 1 |
| Background | Protein KIRREL1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KIRREL1, also known as nephrin-like protein 1, is a transmembrane protein primarily expressed in the glomerular podocytes of the kidney, where it plays a crucial role in filtration barrier integrity. It belongs to the immunoglobulin superfamily, featuring Ig-like domains that mediate cell-cell adhesion and interactions with other proteins in the slit diaphragm, a key structure in glomerular filtration. KIRREL1 is critical for maintaining podocyte structure and function. Mutations in KIRREL1 are associated with nephrotic syndrome, a condition characterized by proteinuria and kidney dysfunction. Its role in stabilizing the filtration barrier makes it essential for renal physiology.
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