Kin of IRRE-Like Protein 1 (KIRREL) Antibody

357.5€ (100 µg)
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935106861
info@markelab.com
name
Kin of IRRE-Like Protein 1 (KIRREL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx146468
tested applications
ELISA, WB
Description
KIRREL Antibody is a Rabbit Polyclonal against KIRREL.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Kin of IRRE-Like Protein 1 (KIRREL) |
Host | Rabbit |
Reactivity | Human |
Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Polyclonal |
Conjugation | Unconjugated |
Isotype | IgG |
Purification | Purified by antigen affinity column chromatography. |
Size 1 | 100 µg |
Size 2 | 1 mg |
Form | Lyophilized |
Tested Applications | ELISA, WB |
Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
Availability | Shipped within 7-15 working days. |
Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | Q96J84 |
Gene ID | 55243 |
NCBI Accession | BC109192 |
Alias | NEPH1,KIRREL,NPHS23,Nephrin-like protein 1,Kin of irregular chiasm-like protein 1,Kin of IRRE-like protein 1 |
Background | Antibody anti-KIRREL1 |
Status | RUO |
Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
KIRREL1, also known as nephrin-like protein 1, is a transmembrane protein primarily expressed in the glomerular podocytes of the kidney, where it plays a crucial role in filtration barrier integrity. It belongs to the immunoglobulin superfamily, featuring Ig-like domains that mediate cell-cell adhesion and interactions with other proteins in the slit diaphragm, a key structure in glomerular filtration. KIRREL1 is critical for maintaining podocyte structure and function. Mutations in KIRREL1 are associated with nephrotic syndrome, a condition characterized by proteinuria and kidney dysfunction. Its role in stabilizing the filtration barrier makes it essential for renal physiology.
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