Kin of IRRE-Like Protein 1 (KIRREL) Antibody

Este producto es parte de KIRREL - kirre like nephrin family adhesion molecule
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292.5€ (80 µl)

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935106861
info@markelab.com
name
Kin of IRRE-Like Protein 1 (KIRREL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx031254
tested applications
ELISA, WB

Description

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Kin of IRRE-Like Protein 1 (KIRREL)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified through a protein A column, followed by peptide affinity purification.
Size 1
80 µl
Size 2
400 µl
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS containing 0.09% sodium azide.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q96J84
Alias
NEPH1,KIRREL,NPHS23,Nephrin-like protein 1,Kin of irregular chiasm-like protein 1,Kin of IRRE-like protein 1
Background
Antibody anti-KIRREL1
Status
RUO

Descripción

KIRREL1, also known as nephrin-like protein 1, is a transmembrane protein primarily expressed in the glomerular podocytes of the kidney, where it plays a crucial role in filtration barrier integrity. It belongs to the immunoglobulin superfamily, featuring Ig-like domains that mediate cell-cell adhesion and interactions with other proteins in the slit diaphragm, a key structure in glomerular filtration. KIRREL1 is critical for maintaining podocyte structure and function. Mutations in KIRREL1 are associated with nephrotic syndrome, a condition characterized by proteinuria and kidney dysfunction. Its role in stabilizing the filtration barrier makes it essential for renal physiology.

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