Mouse Kin Of IRRE-Like Protein 3 (KIRREL3) Protein

Background

KIRREL3, also known as nephrin-like protein 3, is expressed predominantly in the nervous system, particularly in neurons. It is involved in synaptic adhesion, axon guidance, and the formation of neural circuits. KIRREL3 plays an essential role in promoting synaptic specificity, enabling proper connectivity between pre- and postsynaptic neurons. Mutations or deletions in KIRREL3 are associated with neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders. KIRREL3 also plays a role in regulating neuronal plasticity and cognitive processes, such as learning and memory. Its dysfunction underscores its significance in maintaining synaptic integrity and neuronal signaling.