Mouse Kin Of IRRE-Like Protein 3 (KIRREL3) Protein (Active)
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Description
Mouse KIRREL3 Protein is a recombinant protein from Mouse produced in HEK293 Cells. A DNA sequence encoding the mouse KIRREL3 (Q8BR86-1) extracellular domain (Met 1-Ala 535) was expressed, with a C-terminal polyhistidine tag.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | KIRREL3 |
| Host | HEK293 cells |
| Origin | Mouse |
| Observed MW | Molecular Weight: 57.5 kDa Sequence Fragment: Met1-Ala535 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 96% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8BR86-1 |
| Alias | MRD4,KIRRE,NEPH2,PRO4502,Nephrin-like protein 2,Kin of irregular chiasm-like protein 3,Kin of IRRE-like protein 3 |
| Background | Protein KIRREL3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KIRREL3, also known as nephrin-like protein 3, is expressed predominantly in the nervous system, particularly in neurons. It is involved in synaptic adhesion, axon guidance, and the formation of neural circuits. KIRREL3 plays an essential role in promoting synaptic specificity, enabling proper connectivity between pre- and postsynaptic neurons. Mutations or deletions in KIRREL3 are associated with neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders. KIRREL3 also plays a role in regulating neuronal plasticity and cognitive processes, such as learning and memory. Its dysfunction underscores its significance in maintaining synaptic integrity and neuronal signaling.
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