Family main features
Fibroblast Growth Factor Receptor 2 (FGFR2) is one of the four known receptors in the fibroblast growth factor receptor family, which are crucial for the regulation of cell growth, differentiation, and development. The FGFR2 gene is located on chromosome 10q26 and encodes a receptor tyrosine kinase that is activated by fibroblast growth factors (FGFs). FGFR2 plays a vital role in various developmental processes, including limb and craniofacial development, and is implicated in several pathological conditions, such as cancer and congenital disorders.
FGFR2 is expressed in a wide range of tissues, including the brain, skin, bones, and various epithelial tissues. Its expression patterns suggest that it has both broad and specific roles in cellular processes. The receptor's importance is underscored by the diverse effects of its signaling pathways, which influence cellular proliferation, differentiation, migration, and apoptosis.
FGFR2 is a transmembrane protein composed of several distinct domains:
FGFR2 belongs to the FGFR family, which includes FGFR1, FGFR2, FGFR3, and FGFR4. FGFR2 itself has two main isoforms resulting from alternative splicing: FGFR2b (or KGFR) and FGFR2c. These isoforms differ in their ligand-binding specificities and tissue distribution:
These isoforms play distinct roles in development and tissue maintenance, reflecting the versatility and complexity of FGFR2 signaling.
FGFR2 mediates a variety of cellular processes through its interaction with FGFs and subsequent activation of intracellular signaling cascades. Some of its key functions include:
Mutations and aberrant signaling of FGFR2 are associated with various clinical conditions:
FGFR2 is a critical receptor in the FGFR family, playing vital roles in development, tissue maintenance, and disease. Its structure, characterized by distinct extracellular, transmembrane, and intracellular domains, enables it to mediate diverse cellular functions through interactions with FGFs. The receptor's isoforms, FGFR2b and FGFR2c, further expand its functional versatility by binding different FGFs and exhibiting varied tissue distributions.
Clinically, FGFR2 is significant due to its association with developmental disorders like craniosynostosis, various cancers, and skeletal dysplasias. Understanding the molecular mechanisms of FGFR2 signaling and its pathological alterations provides insights into potential therapeutic strategies. As research progresses, FGFR2-targeted therapies hold promise for treating conditions resulting from its dysregulation, highlighting the receptor's importance in both health and disease.
fibroblast growth factor receptor 2 (FGFR2)
BEK,JWS,BBDS,CEK3,CFD1,ECT1,KGFR,TK14,TK25,BFR-1,CD332,K-SAM,Keratinocyte growth factor receptor,FGFR-2
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con FGFR2 - fibroblast growth factor receptor 2
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 33 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | FGFR2 | abx356558 | Chicken Fibroblast Growth Factor Receptor 2 (FGFR2) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 1.56 pg/ml - 100 pg/ml | 0.94 pg/ml | 687.5 | 96 tests | RUO | |
Abbexa | FGFR2 | abx195226 | Human Fibroblast Growth Factor Receptor 2 (FGFR2) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 12.5 pg/ml - 800 pg/ml | 7.5 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | FGFR2 | abx493089 | Human Fibroblast Growth Factor Receptor 2 (FGFR2) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 31.25 pg/ml - 2000 pg/ml | < 12.2 pg/ml | 812.5 | 96 tests | RUO | |
Abbexa | FGFR2 | abx151531 | Human Fibroblast Growth Factor Receptor 2 (FGFR2) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | < 11.9 pg/ml | 662.5 | 96 tests | RUO | |
Abbexa | FGFR2 | abx252457 | Human Fibroblast Growth Factor Receptor 2 (FGFR2) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 493.75 | 96 tests | RUO | |
Abbexa | FGFR2 | abx523860 | Mouse Fibroblast growth factor receptor 2 (FGFR2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P21803 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | FGFR2 | FNab09802 | anti- FGFR2(Phospho-Ser782) Antibody | human | polyclonal | Rabbit | peptide | IgG | Unconjugated | WB | 100µg | P21802 | RUO | |
FineTest | FGFR2 | FNab03102 | anti- FGFR2 antibody | human | polyclonal | Rabbit | fibroblast growth factor receptor 2 | IgG | Unconjugated | ELISA, WB, IF | 100µg | P21802 | RUO | |
Abbexa | FGFR2 | abx122740 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | P21802 | RUO | |
Abbexa | FGFR2 | abx033560 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB, IF/ICC, FCM | 281.25 | 80 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx341858 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx431252 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Goat | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | FGFR2 | abx341860 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody (FITC) | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | FITC | 250 | 50 µl | P21802 | RUO | ||
Abbexa | FGFR2 | abx341859 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody (HRP) | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | HRP | ELISA | 250 | 50 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx172423 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Monoclonal | Mouse | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | FGFR2 | abx033561 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 250 | 80 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx103826 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx341861 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Biotin | ELISA | 250 | 50 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx211619 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx033558 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 250 | 80 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx212984 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, IHC | 250 | 50 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx215353 | Fibroblast Growth Factor Receptor 2 Phospho-Ser782 (FGFR2 pS782) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 Phospho-Ser782 (FGFR2 pS782) | Unconjugated | WB | 350 | 100 µg | P21802 | RUO | |
Abbexa | FGFR2 | abx033559 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx001689 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | IHC | 175 | 20 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx013076 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | WB, IHC | 43.75 | 10 µg | P21802 | RUO | |
Abbexa | FGFR2 | abx402022 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Monoclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB | 287.5 | 50 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx112529 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P21802 | RUO | |
Abbexa | FGFR2 | abx233102 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB, IF/ICC | 350 | 100 µg | P21802 | RUO | |
Abbexa | FGFR2 | abx329256 | Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody | Human | Polyclonal | Rabbit | Fibroblast Growth Factor Receptor 2 (FGFR2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | P21802 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | FGFR2 | abx073879 | Human Fibroblast Growth Factor Receptor 2 (FGFR2) Enzyme | Human | Recombinant | Insect | SDS-PAGE | 225 | 2 µg | P21802 | RUO | |
Abbexa | FGFR2 | abx169303 | Human Fibroblast Growth Factor Receptor 2b (FGFR2b) Protein | Human | Recombinant | HEK293 cells | Unconjugated | WB | 162.5 | 10 µg | P21802-3 | RUO |
Abbexa | FGFR2 | abx066613 | Human Fibroblast Growth Factor Receptor 2 (FGFR2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | P21802 | RUO |
Abbexa | FGFR2 | abx169304 | Human Fibroblast Growth Factor Receptor 2c (FGFR2c) Protein | Human | Recombinant | HEK293 cells | Unconjugated | WB | 162.5 | 10 µg | P21802-1 | RUO |
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