935106861
info@markelab.com
Precio
43.75€ (10 µg)
Rabbit polyclonal antibody against FGFR2 protein. Immunogen region is Internal.
Fibroblast growth factor receptor 2 (FGFR2) FGFR2 is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors (FGFs) to regulate diverse cellular processes such as proliferation, differentiation, migration, and tissue repair. FGFR2 consists of an extracellular ligand-binding domain with three immunoglobulin-like domains, a single-pass transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding induces receptor dimerization and autophosphorylation, initiating downstream signaling cascades such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR2 is crucial in embryonic development, particularly in limb and craniofacial formation, as well as in tissue homeostasis. Mutations in FGFR2 are associated with skeletal disorders like Apert syndrome and Crouzon syndrome, which result from gain-of-function mutations leading to aberrant signaling. FGFR2 dysregulation is also implicated in cancer, particularly in breast and gastric cancers, where it promotes tumor growth, survival, and angiogenesis. Its tissue-specific splicing variants further contribute to its functional diversity across different biological contexts.
Primary Antibodies
Polyclonal
Human, Mouse, Rat
Fibroblast Growth Factor Receptor 2 (FGFR2)
Rabbit
Unconjugated
Liquid
WB, IHC
Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen.
PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol.
10 µg
100 µg
200 µg
300 µg
1 mg
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
FGFR2
No
Shipped within 5-10 working days.
BEK,JWS,BBDS,CEK3,CFD1,ECT1,KGFR,TK14,TK25,BFR-1,CD332,K-SAM,Keratinocyte growth factor receptor,FGFR-2
This product is for research use only.
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Ver másTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in ...
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Ver másTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in ...
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