Human Fibroblast Growth Factor Receptor 2 (FGFR2) Enzyme
234€ (2 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human Fibroblast Growth Factor Receptor 2 (FGFR2) Enzyme
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073879
Tested Applications
SDS-PAGE
Description
Fibroblast Growth Factor Receptor-2 Protein is a recombinant protein kinase.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor Receptor 2 (FGFR2) |
| Host | Insect |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | P21802 |
| Alias | BEK,JWS,BBDS,CEK3,CFD1,ECT1,KGFR,TK14,TK25,BFR-1,CD332,K-SAM,Keratinocyte growth factor receptor,FGFR-2 |
| Background | Protein FGFR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Fibroblast growth factor receptor 2 (FGFR2) FGFR2 is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors (FGFs) to regulate diverse cellular processes such as proliferation, differentiation, migration, and tissue repair. FGFR2 consists of an extracellular ligand-binding domain with three immunoglobulin-like domains, a single-pass transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding induces receptor dimerization and autophosphorylation, initiating downstream signaling cascades such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR2 is crucial in embryonic development, particularly in limb and craniofacial formation, as well as in tissue homeostasis. Mutations in FGFR2 are associated with skeletal disorders like Apert syndrome and Crouzon syndrome, which result from gain-of-function mutations leading to aberrant signaling. FGFR2 dysregulation is also implicated in cancer, particularly in breast and gastric cancers, where it promotes tumor growth, survival, and angiogenesis. Its tissue-specific splicing variants further contribute to its functional diversity across different biological contexts.
Productos relacionados
Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody
FGFR2 Antibody is a Rabbit Polyclonal antibody against FGFR2. The protein encoded by this gene is a member of the fibrob…
Ver producto
Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody
Rabbit polyclonal antibody against FGFR2 protein. Immunogen region is Internal.…
Ver producto
Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody
FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between…
Ver producto