Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody

Este producto es parte de FGFR2 - fibroblast growth factor receptor 2
Fibroblast Growth Factor Receptor 2 (FGFR2) Antibody

Pida mas información

935106861

info@markelab.com

Precio

780€ (1 ml)

Antibody anti-FGFR2

proveedor

Abbexa

reference

abx172423

Tested Applications

WB, IHC, IF/ICC

reactivity

Human

status

RUO

clonality

Monoclonal

Descripción

This product is currently in development. The lead time for this product may be several months. Please contact us at


Background

Fibroblast growth factor receptor 2 (FGFR2) FGFR2 is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors (FGFs) to regulate diverse cellular processes such as proliferation, differentiation, migration, and tissue repair. FGFR2 consists of an extracellular ligand-binding domain with three immunoglobulin-like domains, a single-pass transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding induces receptor dimerization and autophosphorylation, initiating downstream signaling cascades such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR2 is crucial in embryonic development, particularly in limb and craniofacial formation, as well as in tissue homeostasis. Mutations in FGFR2 are associated with skeletal disorders like Apert syndrome and Crouzon syndrome, which result from gain-of-function mutations leading to aberrant signaling. FGFR2 dysregulation is also implicated in cancer, particularly in breast and gastric cancers, where it promotes tumor growth, survival, and angiogenesis. Its tissue-specific splicing variants further contribute to its functional diversity across different biological contexts.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Human


immunogen target

Fibroblast Growth Factor Receptor 2 (FGFR2)


host

Mouse


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by Protein A and Protein G affinity chromatography.


recommended dilution

WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.


buffer

0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.


size 1

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

FGFR2


dry ice

No


availability

Please enquire.


alias

BEK,JWS,BBDS,CEK3,CFD1,ECT1,KGFR,TK14,TK25,BFR-1,CD332,K-SAM,Keratinocyte growth factor receptor,FGFR-2


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