Human Fibroblast Growth Factor Receptor 2c (FGFR2c) Protein
182€ (10 µg)
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Name
Human Fibroblast Growth Factor Receptor 2c (FGFR2c) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx169304
Tested Applications
SDS-PAGE, WB
Description
Human Fibroblast Growth Factor Receptor 2 (FGFR2c) Protein is a recombinant protein produced in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor Receptor 2c (FGFR2c) |
| Host | HEK293 cells |
| Assay Type | Sequence Fragment: 22-377 AA (Isoform 1). Tag: C-terminal 10 His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 41.2 kDa Observed MW (SDS-PAGE): 80 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE, WB |
| Buffer | PBS, containing 20% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Storage: Aliquot and store between -20 °C and -80°C. Avoid repeated freeze/thaw cycles. Stability: Stable for at least 1 month when stored between 2°C and 8°C, or for at least 12 months when stored between -20°C and -80°C. |
| Dry Ice | No |
| UniProt ID | P21802-1 |
| Gene ID | 2263 |
| OMIM | 101200 |
| Alias | BEK,JWS,BBDS,CEK3,CFD1,ECT1,KGFR,TK14,TK25,BFR-1,CD332,K-SAM,Keratinocyte growth factor receptor,FGFR-2 |
| Background | Protein FGFR2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 0.1 ng/µg (1 IEU/µg), as measured by LAL method. |
Background
Fibroblast growth factor receptor 2 (FGFR2) FGFR2 is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors (FGFs) to regulate diverse cellular processes such as proliferation, differentiation, migration, and tissue repair. FGFR2 consists of an extracellular ligand-binding domain with three immunoglobulin-like domains, a single-pass transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding induces receptor dimerization and autophosphorylation, initiating downstream signaling cascades such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR2 is crucial in embryonic development, particularly in limb and craniofacial formation, as well as in tissue homeostasis. Mutations in FGFR2 are associated with skeletal disorders like Apert syndrome and Crouzon syndrome, which result from gain-of-function mutations leading to aberrant signaling. FGFR2 dysregulation is also implicated in cancer, particularly in breast and gastric cancers, where it promotes tumor growth, survival, and angiogenesis. Its tissue-specific splicing variants further contribute to its functional diversity across different biological contexts.
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