935106861
info@markelab.com
Precio
618.75€ (96 tests)
Human Fibroblast Growth Factor Receptor 2 (FGFR2) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Fibroblast Growth Factor Receptor 2 (FGFR2).
Human Fibroblast Growth Factor Receptor 2 (FGFR2) CLIA Kit es un kit CLIA contra el Receptor 2 del Factor de Crecimiento de los Fibroblastos en humanos.
Fibroblast growth factor receptor 2 (FGFR2) FGFR2 is a transmembrane receptor tyrosine kinase that binds fibroblast growth factors (FGFs) to regulate diverse cellular processes such as proliferation, differentiation, migration, and tissue repair. FGFR2 consists of an extracellular ligand-binding domain with three immunoglobulin-like domains, a single-pass transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding induces receptor dimerization and autophosphorylation, initiating downstream signaling cascades such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR2 is crucial in embryonic development, particularly in limb and craniofacial formation, as well as in tissue homeostasis. Mutations in FGFR2 are associated with skeletal disorders like Apert syndrome and Crouzon syndrome, which result from gain-of-function mutations leading to aberrant signaling. FGFR2 dysregulation is also implicated in cancer, particularly in breast and gastric cancers, where it promotes tumor growth, survival, and angiogenesis. Its tissue-specific splicing variants further contribute to its functional diversity across different biological contexts.
CLIA Kits
Fibroblast Growth Factor Receptor 2 (FGFR2)
Human
12.5 pg/ml - 800 pg/ml
7.5 pg/ml
Sandwich
Quantitative
Lyophilized
Chemiluminescent
Serum, plasma and other biological fluids.
96 tests
BEK,JWS,BBDS,CEK3,CFD1,ECT1,KGFR,TK14,TK25,BFR-1,CD332,K-SAM,Keratinocyte growth factor receptor,FGFR-2
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
FGFR2
No
El rango y la sensibilidad pueden variar. Le recomendamos contactar con nosotros a fin de obtener la última información sobre posibles actualizaciones, que no estén representadas en este catalogo. Si necesita un rango específico, contáctenos y trataremos de ayudarle. Consulte sobre posible información que pueda ayudarle a elegir la dilución apropiada para sus muestras. Los kits CLIA están optimizados para la detección de muestras nativas, las proteínas recombinantes, pueden resultar problemáticas a causa de diferencias en la secuencia o cambios en la estructura terciaria.
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Ver másTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in ...
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Ver másTyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in ...
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