Family main features
ITGAX (integrin subunit alpha X), also known as CD11c, is a gene that encodes the alpha X integrin protein. ITGAX pairs with the beta-2 integrin subunit (CD18) to form the heterodimeric receptor αXβ2, also referred to as p150,95 or complement receptor 4 (CR4). ITGAX is primarily expressed on myeloid cells, such as monocytes, macrophages, dendritic cells, and some populations of B cells and natural killer (NK) cells. This integrin is a key mediator of cell adhesion, migration, and immune surveillance, making it a critical component of the innate immune system.
The αXβ2 integrin plays a central role in several immune processes, including phagocytosis, antigen presentation, and the regulation of inflammation. The receptor binds to a variety of ligands, including complement component C3bi, ICAMs (intercellular adhesion molecules), fibrinogen, and matrix proteins such as laminin and fibronectin. Due to its crucial role in immune cell function and its involvement in various pathological conditions, ITGAX has been the subject of extensive scientific research.
The ITGAX protein (CD11c) is a large transmembrane glycoprotein composed of approximately 1,160 amino acids, and it is divided into distinct structural domains, each contributing to its specific functions. Its structure is highly conserved among integrins and features critical elements that enable its adhesive and signaling capabilities.
Extracellular Region:
Transmembrane Domain:
Cytoplasmic Tail:
ITGAX is part of the integrin family, a large family of cell surface receptors composed of heterodimeric complexes. Integrins are categorized based on the alpha and beta subunits they contain. ITGAX pairs with the beta-2 integrin subunit (CD18) to form the heterodimeric receptor known as αXβ2 (p150,95 or CR4). ITGAX belongs to the beta-2 integrin subfamily, which is exclusive to leukocytes.
The beta-2 integrin subfamily, also referred to as leukocyte integrins, includes four major members:
Each of these integrins is specialized for different immune functions but shares a common ability to mediate cell adhesion, migration, and immune activation.
ITGAX, as part of the αXβ2 (CR4) integrin, performs a wide variety of functions that are critical for both innate and adaptive immunity. Some of its key roles include:
Due to its significant role in immune responses, ITGAX has been implicated in a variety of clinical conditions, ranging from autoimmune diseases to chronic inflammatory disorders.
ITGAX (integrin alpha X, CD11c) is an integral component of the immune system, where it forms the αXβ2 (CR4) integrin. This receptor is essential for phagocytosis, antigen presentation, immune cell migration, and the regulation of inflammation. ITGAX's structure includes an extensive extracellular domain for ligand binding, a transmembrane domain for membrane anchoring and dimerization, and a cytoplasmic tail that mediates signaling. ITGAX is predominantly expressed on myeloid cells, particularly dendritic cells, macrophages, and monocytes, where it orchestrates critical immune functions. Dysregulation of ITGAX activity is implicated in several autoimmune, inflammatory, and malignant diseases, making it a potential target for therapeutic interventions.
integrin subunit alpha X (ITGAX)
CD11C,SLEB6,CD11 antigen-like family member C,Leu M5,Leukocyte adhesion glycoprotein p150,95 alpha chain,Leukocyte adhesion receptor p150,95
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con ITGAX - integrin subunit alpha X
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 58 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
Contacta con nosotros en info@markelab.com, si necesitas mas informacion o alguna aclaracion. Te garantizamos respuesta en menos de 24 h.
provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ITGAX | abx259467 | Human Integrin Alpha X / CD11C (ITGAX) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 687.5 | 96 tests | P20702 | RUO |
Abbexa | ITGAX | abx528822 | Mouse Integrin Alpha X (ITGAX) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 675 | 96 tests | Q9QXH4 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ITGAX | abx415362 | Integrin Alpha X / CD11C (ITGAX) Antibody | Cow | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IF/ICC, FCM | 362.5 | 100 µg | RUO | ||
Abbexa | ITGAX | abx413356 | Integrin Alpha X / CD11C (ITGAX) Antibody | Dog | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IHC, FCM, IP | 525 | 2 ml | RUO | ||
FineTest | ITGAX | FNab01413 | anti- CD11c/Integrin alpha X antibody | human | monoclonal | Mouse | integrin, alpha X(complement component 3 receptor 4 subunit) | IgG1 | Unconjugated | ELISA, WB, IHC | 100µg | P20702 | RUO | |
FineTest | ITGAX | FNab01412 | anti- CD11c/Integrin alpha X antibody | human | polyclonal | Rabbit | integrin, alpha X(complement component 3 receptor 4 subunit) | IgG | Unconjugated | ELISA, WB, IHC | 100µg | P20702 | RUO | |
Abbexa | ITGAX | abx411892 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IHC | 587.5 | 50 µg | P20702 | RUO | |
Abbexa | ITGAX | abx339189 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, IHC | 250 | 50 µl | P20702 | RUO | |
Abbexa | ITGAX | abx413692 | Integrin Alpha X / CD11C (ITGAX) Antibody (PE) | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | PE | FCM | 487.5 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx414593 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IHC, FCM | 650 | 100 µg | P20702 | RUO | |
Abbexa | ITGAX | abx229041 | CD11c Antibody (FITC) | Human | Monoclonal | Mouse | CD11c | IgG1 | FITC | FCM | 112.5 | 20 tests | P20702 | RUO |
Abbexa | ITGAX | abx229046 | CD11c Antibody (PE / Cyanine 7) | Human | Monoclonal | Mouse | CD11c | IgG1 | PE / Cyanine 7 | FCM | 125 | 20 tests | P20702 | RUO |
Abbexa | ITGAX | abx033098 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, WB, IHC, IF/ICC, FCM | 250 | 80 µl | P20702 | RUO | |
Abbexa | ITGAX | abx025384 | ITGAX / CD11c Antibody | Human | Monoclonal | Mouse | ITGAX/CD11c | Unconjugated | ELISA, WB | 281.25 | 80 µl | P20702 | RUO | |
Abbexa | ITGAX | abx339188 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, IHC | 250 | 50 µl | P20702 | RUO | |
Abbexa | ITGAX | abx229042 | CD11c Antibody (PE) | Human | Monoclonal | Mouse | CD11c | IgG1 | PE | FCM | 100 | 20 tests | P20702 | RUO |
Abbexa | ITGAX | abx229047 | CD11c Antibody (PE / Cyanine 5.5) | Human | Monoclonal | Mouse | CD11c | IgG1 | PE / Cyanine 5.5 | FCM | 125 | 20 tests | P20702 | RUO |
Abbexa | ITGAX | abx229043 | CD11c Antibody (APC) | Human | Monoclonal | Mouse | CD11c | IgG1 | APC | FCM | 137.5 | 20 tests | P20702 | RUO |
Abbexa | ITGAX | abx229048 | CD11c Antibody (PerCP / Cyanine 5.5) | Human | Monoclonal | Mouse | CD11c | IgG1 | PerCP / Cyanine 5.5 | FCM | 200 | 20 tests | P20702 | RUO |
Abbexa | ITGAX | abx229050 | CD11c Antibody (AF647) | Human | Monoclonal | Mouse | CD11c | AF647 | FCM | 212.5 | 20 tests | P20702 | RUO | |
Abbexa | ITGAX | abx229049 | CD11c Antibody (AF488) | Human | Monoclonal | Mouse | CD11c | AF488 | FCM | 212.5 | 20 tests | P20702 | RUO | |
Abbexa | ITGAX | abx229044 | CD11c Antibody (PerCP) | Human | Monoclonal | Mouse | CD11c | PerCP | FCM | 212.5 | 20 tests | P20702 | RUO | |
Abbexa | ITGAX | abx025383 | ITGAX / CD11c Antibody | Human | Monoclonal | Mouse | ITGAX/CD11c | Unconjugated | ELISA, WB | 518.75 | 100 µl | P20702 | RUO | |
Abbexa | ITGAX | abx413690 | Integrin Alpha X / CD11C (ITGAX) Antibody (FITC) | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | FITC | FCM | 175 | 25 µg | P20702 | RUO | |
Abbexa | ITGAX | abx104960 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ITGAX | abx413694 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IHC, FCM, IP | 175 | 25 µg | P20702 | RUO | |
Abbexa | ITGAX | abx139634 | Integrin Alpha X / CD11C (ITGAX) Antibody (APC) | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | APC | FCM | 400 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx139631 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IHC-F, FCM, IP | 287.5 | 0.1 mg | P20702 | RUO | |
Abbexa | ITGAX | abx139632 | Integrin Alpha X / CD11C (ITGAX) Antibody (PerCP) | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | PerCP | FCM | 400 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx139633 | Integrin Alpha X / CD11C (ITGAX) Antibody (PE) | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | PE | FCM | 400 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx139635 | Integrin Alpha X / CD11C (ITGAX) Antibody (FITC) | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | FITC | FCM | 350 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx347093 | Integrin Alpha-X (ITGAX) Antibody (PerCP / Cyanine 5.5) | Human | Monoclonal | Mouse | Integrin Alpha-X (ITGAX) | PerCP / Cyanine 5.5 | FCM | 562.5 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx140931 | Integrin Alpha-X (ITGAX) Antibody (APC / Cyanine 7) | Human | Monoclonal | Mouse | Integrin Alpha-X (ITGAX) | APC / Cyanine 7 | FCM | 437.5 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx140985 | Integrin Alpha-X (ITGAX) Antibody (APC / Cyanine 7) | Human | Monoclonal | Mouse | Integrin Alpha-X (ITGAX) | APC / Cyanine 7 | FCM | 437.5 | 100 tests | P20702 | RUO | |
Abbexa | ITGAX | abx322638 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, WB, IHC, IF/ICC | 250 | 50 µl | P20702 | RUO | |
Abbexa | ITGAX | abx113189 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | P20702 | RUO | |
Abbexa | ITGAX | abx231413 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Monoclonal | Mouse | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P20702 | RUO | |
Abbexa | ITGAX | abx124171 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | WB, IF/ICC | 175 | 20 µl | P20702 | RUO | |
Abbexa | ITGAX | abx231412 | Integrin Alpha X / CD11C (ITGAX) Antibody | Human | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | ELISA, WB, IHC | 350 | 100 µg | P20702 | RUO | |
Abbexa | ITGAX | abx413007 | Integrin Alpha X / CD11C (ITGAX) Antibody (FITC) | Mouse | Monoclonal | Hamster | Integrin Alpha X / CD11C (ITGAX) | FITC | FCM | 400 | 100 µg | Q9QXH4 | RUO | |
Abbexa | ITGAX | abx228047 | CD11c Antibody (PE / Cyanine 7) | Mouse | Monoclonal | Hamster | CD11c | IgG | PE / Cyanine 7 | FCM | 100 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228041 | CD11c Antibody (Biotin) | Mouse | Monoclonal | Hamster | CD11c | IgG | Biotin | FCM | 62.5 | 25 µg | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228043 | CD11c Antibody (PE) | Mouse | Monoclonal | Hamster | CD11c | IgG | PE | FCM | 62.5 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx413011 | Integrin Alpha X / CD11C (ITGAX) Antibody | Mouse | Monoclonal | Hamster | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | IHC, IF/ICC, FCM, IP | 175 | 25 µg | Q9QXH4 | RUO | |
Abbexa | ITGAX | abx129411 | Integrin Alpha X / CD11C (ITGAX) Antibody | Mouse | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ITGAX | abx274308 | Integrin Alpha X / CD11C (ITGAX) Antibody (Biotin) | Mouse | Polyclonal | Rabbit | Integrin Alpha X / CD11C (ITGAX) | Biotin | WB, IHC, IF/ICC | 362.5 | 200 µl | RUO | ||
Abbexa | ITGAX | abx228045 | CD11c Antibody (PerCP) | Mouse | Monoclonal | Hamster | CD11c | PerCP | FCM | 100 | 50 tests | Q9QXH4 | RUO | |
Abbexa | ITGAX | abx228046 | CD11c Antibody (PE / Cyanine 5) | Mouse | Monoclonal | Hamster | CD11c | IgG | PE / Cyanine 5 | FCM | 100 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228044 | CD11c Antibody (APC) | Mouse | Monoclonal | Hamster | CD11c | IgG | APC | FCM | 62.5 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228048 | CD11c Antibody (PE / Cyanine 5.5) | Mouse | Monoclonal | Hamster | CD11c | IgG | PE / Cyanine 5.5 | FCM | 100 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228050 | CD11c Antibody (AF488) | Mouse | Monoclonal | Hamster | CD11c | IgG | AF488 | FCM | 100 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx413009 | Integrin Alpha X / CD11C (ITGAX) Antibody (PE) | Mouse | Monoclonal | Hamster | Integrin Alpha X / CD11C (ITGAX) | PE | FCM | 487.5 | 100 tests | Q9QXH4 | RUO | |
Abbexa | ITGAX | abx228049 | CD11c Antibody (PerCP / Cyanine 5.5) | Mouse | Monoclonal | Hamster | CD11c | IgG | PerCP / Cyanine 5.5 | FCM | 100 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228042 | CD11c Antibody (FITC) | Mouse | Monoclonal | Hamster | CD11c | IgG | FITC | FCM | 62.5 | 50 tests | Q9QXH4 | RUO |
Abbexa | ITGAX | abx228051 | CD11c Antibody (AF647) | Mouse | Monoclonal | Hamster | CD11c | IgG | AF647 | FCM | 100 | 50 tests | Q9QXH4 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | ITGAX | P0541 | Recombinant Human CD11c | Human | Recombinant | E.Coli | Western Blot, ELISA | 50μg | P20702 | RUO | ||
Abbexa | ITGAX | abx167234 | Mouse Integrin Alpha X / CD11C (ITGAX) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO | |
Abbexa | ITGAX | abx166474 | Human Integrin Alpha X / CD11C (ITGAX) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO |
Te recomendamos que si no encuentras lo que buscas, utilices el buscador, refinando la búsqueda según tu criterio y usando Alias, o bien contacta con nosotros.