ITGAX antibody
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935106861
info@markelab.com
name
ITGAX antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01413
tested applications
ELISA, WB, IHC
Description
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits. CD11c/Integrin alpha X is a type I transmembrane protein present on a variety of cells, including monocytes/macrophages, granulocytes, NK cells and dendritic cells. Integrin alpha X/beta 2 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | integrin, alpha X(complement component 3 receptor 4 subunit) (ITGAX) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1:500-1:5000; IHC: 1:100-1:400 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 5D4 |
| Observed MW | 150 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, WB, IHC |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P20702 |
| Alias | CD11C,SLEB6,CD11 antigen-like family member C,Leu M5,Leukocyte adhesion glycoprotein p150,95 alpha chain,Leukocyte adhesion receptor p150,95 |
| Background | Antibody anti-ITGAX |
| Status | RUO |
| Note | Mol. Weight 150 kDa |
Descripción
Integrin Subunit Alpha X (ITGAX), commonly referred to as CD11c, is a member of the integrin family that dimerizes with ITGB2 to form the CR4 receptor. ITGAX is highly expressed on dendritic cells and is used as a hallmark marker for this cell type. It mediates cell adhesion, migration, and antigen presentation by enabling dendritic cells to interact with the extracellular matrix and other immune cells. ITGAX also participates in phagocytosis and immune responses against pathogens by functioning as a complement receptor. Its role in immune regulation makes it a focus in studies of chronic inflammatory diseases, atherosclerosis, and cancer immunology. The protein's expression is also commonly analyzed in histological studies to evaluate dendritic cell populations in various tissues.
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