ITGAX antibody

Este producto es parte de ITGAX - integrin subunit alpha X
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935106861
info@markelab.com
name
ITGAX antibody
category
Primary Antibodies
provider
FineTest
reference
FNab01412
tested applications
ELISA, WB, IHC

Description

Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits. CD11c/Integrin alpha X is a type I transmembrane protein present on a variety of cells, including monocytes/macrophages, granulocytes, NK cells and dendritic cells. Integrin alpha X/beta 2 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
integrin, alpha X(complement component 3 receptor 4 subunit) (ITGAX)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB:1:200-1:2000; IHC:1:50-1:200
Clonality
polyclonal
Conjugation
Unconjugated
Isotype
IgG
Observed MW
150 kDa
Purity
≥95% as determined by SDS-PAGE
Purification
Immunogen affinity purified
Size 1
100µg
Form
liquid
Tested Applications
ELISA, WB, IHC
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
UniProt ID
P20702
Alias
CD11C,SLEB6,CD11 antigen-like family member C,Leu M5,Leukocyte adhesion glycoprotein p150,95 alpha chain,Leukocyte adhesion receptor p150,95
Background
Antibody anti-ITGAX
Status
RUO
Note
Mol. Weight 150 kDa

Descripción

Integrin Subunit Alpha X (ITGAX), commonly referred to as CD11c, is a member of the integrin family that dimerizes with ITGB2 to form the CR4 receptor. ITGAX is highly expressed on dendritic cells and is used as a hallmark marker for this cell type. It mediates cell adhesion, migration, and antigen presentation by enabling dendritic cells to interact with the extracellular matrix and other immune cells. ITGAX also participates in phagocytosis and immune responses against pathogens by functioning as a complement receptor. Its role in immune regulation makes it a focus in studies of chronic inflammatory diseases, atherosclerosis, and cancer immunology. The protein's expression is also commonly analyzed in histological studies to evaluate dendritic cell populations in various tissues.

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