Family main features
LINGO proteins, also known as Leucine-Rich Repeat and Ig Domain Containing (LRR and Ig domain-containing), are critical players in the nervous system's development and functioning. These proteins are characterized by their unique structure, which includes leucine-rich repeat (LRR) domains and immunoglobulin (Ig) domains. They are primarily expressed in the central nervous system (CNS) and play pivotal roles in regulating axonal myelination, neural repair, and synaptic plasticity. LINGO proteins are highly conserved across species, indicating their fundamental role in neural physiology.
The structure of LINGO proteins is highly specialized and allows them to perform their functions effectively:
LINGO proteins are classified based on their structural characteristics and their role in neural functions. The most studied member of this family is LINGO-1, but there are other related proteins, including LINGO-2, LINGO-3, and LINGO-4, each with distinct but sometimes overlapping functions:
LINGO proteins are multifunctional and play significant roles in the nervous system:
Alterations in the expression and function of LINGO proteins have been linked to several neurological disorders:
LINGO proteins are crucial regulators of neural development, repair, and plasticity, with LINGO-1 being the most well-characterized member. These proteins inhibit myelination and axonal regeneration, ensuring precise control over neural development and response to injury. Alterations in LINGO protein function are implicated in various neurological and psychiatric disorders, making them significant targets for therapeutic intervention. Understanding the complex roles of LINGO proteins in the nervous system continues to be a critical area of research with substantial implications for treating neurological diseases.
leucine rich repeat and Ig domain containing 1 (LINGO1)
LERN1,MRT64,LRRN6A,UNQ201,Leucine-rich repeat neuronal protein 6A,Leucine-rich repeat neuronal protein 1,Leucine-rich repeat and immunoglobulin domain-containing protein 1,Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
leucine rich repeat and Ig domain containing 2 (LINGO2)
LERN3,LRRN6CLeucine-rich repeat neuronal protein 6C,Leucine-rich repeat neuronal protein 3,Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
leucine rich repeat and Ig domain containing 3 (LINGO3)
LERN2,LRRN6B,Leucine-rich repeat neuronal protein 6B,Leucine-rich repeat neuronal protein 2,Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3
leucine rich repeat and Ig domain containing 4 (LINGO4)
LRRN6D,DAAT9248,PRO34002,Leucine-rich repeat neuronal protein 6D,Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con LINGO - leucine rich repeat and Ig domain containing
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LINGO1 | abx388285 | Human Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) ELISA Kit | Human | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.625 ng/ml - 40 ng/ml | < 0.29 ng/ml | 687.5 | 96 tests | Q96FE5 | RUO |
Abbexa | LINGO2 | abx531005 | Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q7L985 | RUO | ||
Abbexa | LINGO3 | abx531007 | Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LINGO3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P0C6S8 | RUO | ||
Abbexa | LINGO4 | abx531009 | Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 4 (LINGO4) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6UY18 | RUO | ||
Abbexa | LINGO1 | abx531004 | Mouse Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.11 ng/ml | 687.5 | 96 tests | Q9D1T0 | RUO |
Abbexa | LINGO2 | abx531006 | Mouse Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2 (LINGO2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q3URE9 | RUO | ||
Abbexa | LINGO3 | abx531008 | Mouse Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LINGO3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q6GQU6 | RUO | ||
Abbexa | LINGO4 | abx531010 | Mouse Leucine-rich repeat and immunoglobulin-like domain containing-NOGO receptor-interacting protein 4 (LINGO4) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q149C3 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | LINGO1 | FNab04792 | anti- LINGO1 antibody | human | polyclonal | Rabbit | leucine rich repeat and Ig domain containing 1 | IgG | Unconjugated | ELISA, WB | 100µg | Q96FE5 | RUO | |
Abbexa | LINGO1 | abx033301 | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q96FE5 | RUO | |
Abbexa | LINGO1 | abx033300 | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) | Unconjugated | ELISA, WB, IHC | 250 | 80 µl | Q96FE5 | RUO | |
Abbexa | LINGO1 | abx032074 | LINGO-1 (LRRN6A) (pS596) Antibody | Human | Polyclonal | Rabbit | LINGO-1 (LRRN6A) (pS596) | Unconjugated | ELISA, DB | 281.25 | 80 µl | Q9D1T0 | RUO | |
Abbexa | LINGO1 | abx322636 | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q96FE5 | RUO | |
Abbexa | LINGO1 | abx032410 | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 (LINGO-1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 1 (LINGO-1) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | Q9D1T0 | RUO | |
Abbexa | LINGO1 | abx123969 | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) | Unconjugated | WB | 175 | 20 µl | Q96FE5 | RUO | |
Abbexa | LINGO1 | abx113464 | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | Q96FE5 | RUO | |
Abbexa | LINGO1 | abx234792 | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) | Unconjugated | ELISA, WB | 350 | 100 µg | Q96FE5 | RUO | |
Abbexa | LINGO2 | abx031261 | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 2 (LINGO2) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 2 (LINGO2) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q7L985 | RUO | |
Abbexa | LINGO3 | abx028641 | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 3 (LINGO3) Antibody | Human | Polyclonal | Rabbit | Leucine-Rich Repeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-Interacting Protein 3 (LINGO3) | Unconjugated | ELISA, WB | 250 | 80 µl | P0C6S8 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | LINGO1 | abx680420 | Human Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Protein | Human | Recombinant | E. coli | Unconjugated | SDS-PAGE | 225 | 5 µg | RUO |
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