Human Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) ELISA Kit
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Description
Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 ELISA Kit is an ELISA kit against Human Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1).
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.625 ng/ml - 40 ng/ml |
| Sensitivity | < 0.29 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q96FE5 |
| Gene ID | 84894 |
| OMIM | 609791 |
| Alias | LERN1,MRT64,LRRN6A,UNQ201,Leucine-rich repeat neuronal protein 6A,Leucine-rich repeat neuronal protein 1,Leucine-rich repeat and immunoglobulin domain-containing protein 1,Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 |
| Background | Elisa kits for LINGO1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LINGO1 is a transmembrane protein predominantly expressed in the central nervous system (CNS) and is involved in the regulation of neuronal and oligodendrocyte function. Structurally, it contains leucine-rich repeats (LRRs) and immunoglobulin (Ig) domains that facilitate protein-protein interactions. LINGO1 plays a critical role in inhibiting axonal regeneration and myelination by interacting with receptors like Nogo receptor 1 (NgR1) in neuronal signaling pathways. Its overexpression has been implicated in neurodegenerative diseases such as multiple sclerosis (MS) and Parkinson’s disease, where impaired remyelination and axonal repair contribute to disease progression. LINGO1 has emerged as a therapeutic target in CNS disorders, with LINGO1 antagonists showing promise in preclinical studies for promoting remyelination and neural repair. Genetic polymorphisms in LINGO1 have also been associated with susceptibility to essential tremor, highlighting its significance in movement disorders.
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