Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) Antibody
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Description
LINGO1 is a functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. It is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leucine-Rich Repeat Neuronal Protein 1 (LINGO1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000, IHC-P: 1/10 - 1/400. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96FE5 |
| Alias | LERN1,MRT64,LRRN6A,UNQ201,Leucine-rich repeat neuronal protein 6A,Leucine-rich repeat neuronal protein 1,Leucine-rich repeat and immunoglobulin domain-containing protein 1,Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 |
| Background | Antibody anti-LINGO1 |
| Status | RUO |
Descripción
LINGO1 is a transmembrane protein predominantly expressed in the central nervous system (CNS) and is involved in the regulation of neuronal and oligodendrocyte function. Structurally, it contains leucine-rich repeats (LRRs) and immunoglobulin (Ig) domains that facilitate protein-protein interactions. LINGO1 plays a critical role in inhibiting axonal regeneration and myelination by interacting with receptors like Nogo receptor 1 (NgR1) in neuronal signaling pathways. Its overexpression has been implicated in neurodegenerative diseases such as multiple sclerosis (MS) and Parkinson’s disease, where impaired remyelination and axonal repair contribute to disease progression. LINGO1 has emerged as a therapeutic target in CNS disorders, with LINGO1 antagonists showing promise in preclinical studies for promoting remyelination and neural repair. Genetic polymorphisms in LINGO1 have also been associated with susceptibility to essential tremor, highlighting its significance in movement disorders.
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