Family main features
DNA Fragmentation Factor Subunit Alpha (DFFA), also known as ICAD (Inhibitor of Caspase-Activated DNase), is a critical protein involved in the regulation of apoptosis. Apoptosis is a programmed cell death process essential for development, tissue homeostasis, and the elimination of damaged or harmful cells. DFFA serves as the regulatory subunit of the DNA Fragmentation Factor (DFF), which also includes the catalytic subunit DFFB (CAD, Caspase-Activated DNase). In healthy cells, DFFA binds to and inhibits DFFB, preventing it from cleaving DNA. During apoptosis, caspases cleave DFFA, releasing DFFB to initiate the fragmentation of chromosomal DNA, a hallmark of apoptosis. DFFA is ubiquitously expressed, reflecting its fundamental role in cellular homeostasis and apoptotic regulation.
DFFA’s structure includes several domains and motifs that facilitate its regulatory functions:
DFFA is classified within the family of apoptosis regulators, specifically as an inhibitor of DNase activity within the apoptotic pathway:
DFFA is involved in several critical cellular functions related to apoptosis:
Alterations in DFFA function or expression are associated with various diseases:
DNA Fragmentation Factor Subunit Alpha (DFFA), also known as ICAD, is a crucial regulatory protein in the apoptosis pathway. It inhibits the catalytic activity of DFFB (CAD) under normal conditions, preventing DNA fragmentation. Upon apoptotic signaling, caspase-mediated cleavage of DFFA releases and activates DFFB, leading to the controlled fragmentation of chromosomal DNA. DFFA's regulatory functions are vital for maintaining genomic stability and ensuring proper execution of apoptosis. Dysregulation of DFFA is associated with cancer, neurodegenerative diseases, and autoimmune conditions. Understanding DFFA's role and regulation is essential for developing therapeutic strategies targeting apoptosis-related diseases.
DNA fragmentation factor subunit alpha (DFFA)
DFF-45, DFF1, ICAD, Inhibitor of caspase-activated DNase,DFF45,DFFA
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, ELISA Kits) relacionados con DFFA - DNA fragmentation factor subunit alpha
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Esta página contiene 20 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | DFFA | abx259541 | Human DNA Fragmentation Factor Subunit Alpha (DFFA) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | O00273 | RUO |
Abbexa | DFFA | abx510235 | Mouse DNA fragmentation factor subunit alpha (DFFA) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O54786 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
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FineTest | DFFA | FNab02347 | anti- DFF45/DFFA antibody | human | polyclonal | Rabbit | DNA fragmentation factor, 45kDa, alpha polypeptide | IgG | Unconjugated | ELISA, WB, IHC, IP, IF | 100µg | O00273 | RUO | |
Abbexa | DFFA | abx037485 | DFFA / ICAD Antibody | Human | Polyclonal | Rabbit | DFFA/ICAD | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | DFFA | abx015539 | DNA Fragmentation Factor 45 kDa Subunit Cleaved-Asp224 (DFF45 Cleaved-D224) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor 45 kDa Subunit Cleaved-Asp224 (DFF45 Cleaved-D224) | Unconjugated | IHC | 43.75 | 10 µg | O00273 | RUO | |
Abbexa | DFFA | abx034309 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, WB | 281.25 | 80 µl | O00273 | RUO | |
Abbexa | DFFA | abx232347 | DNA Fragmentation Factor 45 KDa Subunit (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor 45 KDa Subunit (DFFA) | Unconjugated | ELISA, WB, IHC, IF/ICC, IP | 350 | 100 µg | O00273 | RUO | |
Abbexa | DFFA | abx038208 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | DFFA | abx321385 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, WB, IHC, IP | 237.5 | 50 µl | O00273 | RUO | |
Abbexa | DFFA | abx324535 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | O00273 | RUO | |
Abbexa | DFFA | abx339734 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, IHC | 250 | 50 µl | O00273 | RUO | |
Abbexa | DFFA | abx128885 | DNA Fragmentation Factor Subunit Alpha (DFFa) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFa) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | O00273 | RUO | |
Abbexa | DFFA | abx112116 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, WB, IHC | 612.5 | 100 µl | O00273 | RUO | |
Abbexa | DFFA | abx329426 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | O00273 | RUO | |
Abbexa | DFFA | abx007165 | DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody | Human | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFA) | Unconjugated | WB, IF/ICC | 200 | 20 µl | O00273 | RUO | |
Abbexa | DFFA | abx129723 | DNA Fragmentation Factor Subunit Alpha (DFFa) Antibody | Mouse | Polyclonal | Rabbit | DNA Fragmentation Factor Subunit Alpha (DFFa) | Unconjugated | WB, IHC, IF/ICC | 287.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | DFFA | abx167514 | Mouse DNA Fragmentation Factor Subunit Alpha (DFFa) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
FineTest | DFFA | P4044 | Recombinant Human ICAD | Human | Recombinant | E.Coli | Western Blot,ELISA | 50μg | O00273 | RUO | ||
Abbexa | DFFA | abx261772 | DNA Fragmentation Factor Subunit Alpha (DFFA) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | O00273 | RUO | ||
Abbexa | DFFA | abx167049 | Human DNA Fragmentation Factor Subunit Alpha (DFFa) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | O00273 | RUO |
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