DNA Fragmentation Factor Subunit Alpha (DFFa) Antibody
299€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
DNA Fragmentation Factor Subunit Alpha (DFFa) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx129723
Tested Applications
WB, IHC
Description
DNA Fragmentation Factor Subunit Alpha Antibody is a Rabbit Polyclonal against DNA Fragmentation Factor Subunit Alpha.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: DNA Fragmentation Factor Subunit Alpha (DFFa) Immunogen: DFFa (Lys19-Ser262) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | DFF-45, DFF1, ICAD, Inhibitor of caspase-activated DNase,DFF45,DFFA |
| Background | Antibody anti-DFFA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
DNA fragmentation factor subunit alpha (DFFA) acts as the regulatory component of the DFF complex, forming a heterodimer with DFFB. DFFA functions primarily as an inhibitor of DFFB, maintaining it in an inactive state in healthy cells. Upon receiving apoptotic signals, caspases cleave DFFA, thereby releasing and activating DFFB. This cleavage event is a critical checkpoint in the apoptotic pathway, ensuring that DNA fragmentation occurs only during apoptosis. Beyond its role as a DFFB inhibitor, DFFA is implicated in nuclear condensation, which occurs concurrently with DNA fragmentation. Alterations in DFFA expression or function can influence the cell's ability to undergo programmed cell death, impacting both normal tissue homeostasis and disease processes, such as tumorigenesis or immune-related disorders.
Productos relacionados
DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody
DFFA Antibody is a Rabbit Polyclonal Antibody against DFFA.…
Ver producto
DNA Fragmentation Factor 45 kDa Subunit Cleaved-Asp224 (DFF45 Cleaved-D224) Antibody
Rabbit polyclonal antibody against DFF45 protein. Immunogen region is Internal. Specificity is as follows for the reacti…
Ver producto
DNA Fragmentation Factor Subunit Alpha (DFFA) Antibody
DFFA is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process…
Ver producto