Human DNA Fragmentation Factor Subunit Alpha (DFFA) ELISA Kit

Este producto es parte de DFFA - DNA fragmentation factor subunit alpha
Human DNA Fragmentation Factor Subunit Alpha (DFFA) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

715€ (96 tests)

Elisa kits for DFFA

proveedor

Abbexa

reference

abx259541

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human DNA Fragmentation Factor Subunit Alpha (DFFA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DFF45/DFFA concentrations in tissue homogenates, cell lysates and other biological fluids.


Background

DNA fragmentation factor subunit alpha (DFFA) acts as the regulatory component of the DFF complex, forming a heterodimer with DFFB. DFFA functions primarily as an inhibitor of DFFB, maintaining it in an inactive state in healthy cells. Upon receiving apoptotic signals, caspases cleave DFFA, thereby releasing and activating DFFB. This cleavage event is a critical checkpoint in the apoptotic pathway, ensuring that DNA fragmentation occurs only during apoptosis. Beyond its role as a DFFB inhibitor, DFFA is implicated in nuclear condensation, which occurs concurrently with DNA fragmentation. Alterations in DFFA expression or function can influence the cell's ability to undergo programmed cell death, impacting both normal tissue homeostasis and disease processes, such as tumorigenesis or immune-related disorders.

Características del producto

category

ELISA Kits


immunogen target

DNA Fragmentation Factor Subunit Alpha (DFFA)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


form

Lyophilized


detection method

Colorimetric


sample type

Tissue homogenates, cell lysates and other biological fluids.


size 1

96 tests


alias

DFF-45, DFF1, ICAD, Inhibitor of caspase-activated DNase,DFF45,DFFA


storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.


or code

DFFA


dry ice

No


note

This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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reactivity

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status

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clonality

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