DNA Fragmentation Factor 45 kDa Subunit Cleaved-Asp224 (DFF45 Cleaved-D224) Antibody
52€ (10 µg)
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935106861
info@markelab.com
name
DNA Fragmentation Factor 45 kDa Subunit Cleaved-Asp224 (DFF45 Cleaved-D224) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015539
tested applications
IHC
Description
Rabbit polyclonal antibody against DFF45 protein. Immunogen region is Internal. Specificity is as follows for the reactive species: H:D224.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | DNA Fragmentation Factor 45 kDa Subunit Cleaved-Asp224 (DFF45 Cleaved-D224) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Cleaved // Target Modification: Asp224 |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00273 |
| Alias | DFF-45, DFF1, ICAD, Inhibitor of caspase-activated DNase,DFF45,DFFA |
| Background | Antibody anti-DFFA |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
DNA fragmentation factor subunit alpha (DFFA) acts as the regulatory component of the DFF complex, forming a heterodimer with DFFB. DFFA functions primarily as an inhibitor of DFFB, maintaining it in an inactive state in healthy cells. Upon receiving apoptotic signals, caspases cleave DFFA, thereby releasing and activating DFFB. This cleavage event is a critical checkpoint in the apoptotic pathway, ensuring that DNA fragmentation occurs only during apoptosis. Beyond its role as a DFFB inhibitor, DFFA is implicated in nuclear condensation, which occurs concurrently with DNA fragmentation. Alterations in DFFA expression or function can influence the cell's ability to undergo programmed cell death, impacting both normal tissue homeostasis and disease processes, such as tumorigenesis or immune-related disorders.
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