Family main features
Toll-like receptor 1 (TLR1) is a member of the toll-like receptor (TLR) family, a critical component of the innate immune system that detects and responds to pathogens through pattern recognition. TLRs are integral to recognizing pathogen-associated molecular patterns (PAMPs), which are conserved molecular structures in microbes, such as bacterial cell wall components. TLR1, in particular, functions predominantly as a co-receptor with TLR2 and recognizes lipoproteins and lipopeptides derived from bacterial membranes. By binding these ligands, TLR1 initiates intracellular signaling pathways that activate pro-inflammatory cytokine production and immune cell recruitment, key processes for mounting an immune response against infection.
TLR1 is primarily expressed on immune cells like monocytes, macrophages, dendritic cells, and neutrophils, and is involved in host defense against bacterial, fungal, and some viral pathogens. Its role in immune responses makes TLR1 a valuable focus for understanding immune signaling pathways and developing potential treatments for infections, inflammatory diseases, and cancers.
The TLR1 protein consists of around 786 amino acids and has a well-defined structure characterized by distinct functional domains:
Extracellular Domain:
Transmembrane Domain:
Intracellular Domain (TIR Domain):
TLR1 is classified within the TLR family and is a part of the TLR1 subfamily, which also includes TLR6 and TLR10. These TLRs share similar structures and form heterodimers with other TLRs, particularly TLR2, to broaden their ligand recognition capacities:
Each TLR within this subfamily shows specificity for distinct ligand types, though they share functional similarities in immune system activation.
TLR1 is primarily involved in recognizing specific bacterial lipopeptides, initiating immune responses by binding these microbial molecules and activating downstream signaling pathways:
Ligand Recognition and TLR2 Heterodimerization:
Signal Transduction:
Role in Host Defense:
Abnormalities in TLR1 function or expression are associated with a range of infectious, autoimmune, and inflammatory diseases:
Genetic Variants and Susceptibility to Infections:
Autoimmune Diseases:
Cancer:
Therapeutic Targeting:
TLR1 is an essential component of the innate immune system, involved in detecting bacterial lipoproteins and activating immune responses. The TLR1/TLR2 heterodimer enables recognition of a broader range of pathogens, initiating downstream signaling through the MyD88-dependent pathway, which culminates in the production of pro-inflammatory cytokines and immune cell recruitment. Structurally, TLR1 is characterized by leucine-rich repeats in its extracellular domain, a single-pass transmembrane region, and a TIR domain crucial for intracellular signaling.
Clinically, TLR1 polymorphisms affect susceptibility to infections and have implications in autoimmune diseases, inflammatory disorders, and cancer. Its involvement in these conditions makes TLR1 a potential therapeutic target for immune modulation in diseases where excessive or insufficient immune responses play a critical role. As research continues, TLR1-targeted therapies may become viable options for improving patient outcomes in infectious diseases, autoimmune conditions, and oncology.
toll like receptor 1 (TLR1)
Toll-like receptor 1,TIL,CD281,rsc786,TIL. LPRS5,Toll/interleukin-1 receptor-like protein
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, Primary Antibodies, CLIA Kits, ELISA Kits) relacionados con TLR1 - toll like receptor 1
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 32 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
FineTest | TLR1 | EH4220 | Human CD281/TLR1(Toll-like receptor 1) ELISA Kit | human | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q15399 | RUO | ||
Abbexa | TLR1 | abx493338 | Human Toll Like Receptor 1 (TLR1) CLIA Kit | Human | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.114 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | TLR1 | abx153340 | Human Toll Like Receptor 1 (TLR1) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 662.5 | 96 tests | Q15399 | RUO |
Abbexa | TLR1 | abx570435 | Human Toll Like Receptor 1 (TLR1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | 0.19 ng/ml | 587.5 | 96 tests | Q15399 | RUO |
FineTest | TLR1 | EM0708 | Mouse TLR1(Toll-like receptor 1) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9EPQ1 | RUO | ||
Abbexa | TLR1 | abx154783 | Mouse Toll Like Receptor 1 (TLR1) ELISA Kit | Mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.11 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | TLR1 | abx493339 | Mouse Toll Like Receptor 1 (TLR1) CLIA Kit | Mouse | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.108 ng/ml | 812.5 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR1 | abx273662 | Toll Like Receptor 1 (TLR1) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | FITC | WB, IHC, IF/ICC | 412.5 | 200 µl | RUO | ||
Abbexa | TLR1 | abx131782 | Toll Like Receptor 1 (TLR1) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 1 (TLR1) | Unconjugated | WB, IHC, IF/ICC | 337.5 | 100 µl | Q15399 | RUO | |
Abbexa | TLR1 | abx272228 | Toll Like Receptor 1 (TLR1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Biotin | WB, IHC, IF/ICC | 350 | 200 µl | RUO | ||
Abbexa | TLR1 | abx313156 | Toll-Like Receptor 1 (TLR1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | Biotin | ELISA | 162.5 | 20 µg | Q15399 | RUO | |
Abbexa | TLR1 | abx313154 | Toll-Like Receptor 1 (TLR1) Antibody (HRP) | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | HRP | ELISA | 162.5 | 20 µg | Q15399 | RUO | |
Abbexa | TLR1 | abx313155 | Toll-Like Receptor 1 (TLR1) Antibody (FITC) | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | FITC | 162.5 | 20 µg | Q15399 | RUO | ||
Abbexa | TLR1 | abx270878 | Toll Like Receptor 1 (TLR1) Antibody (PE) | Human | Monoclonal | Mouse | Toll Like Receptor 1 (TLR1) | PE | FCM | 575 | 100 tests | RUO | ||
Abbexa | TLR1 | abx145022 | Toll-Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | TLR1 | abx174837 | Toll Like Receptor 1 (TLR1) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 1 (TLR1) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | TLR1 | abx102057 | Toll Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q15399 | RUO | |
Abbexa | TLR1 | abx313153 | Toll-Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q15399 | RUO | |
Abbexa | TLR1 | abx270646 | Toll Like Receptor 1 (TLR1) Antibody (APC) | Human | Monoclonal | Mouse | Toll Like Receptor 1 (TLR1) | APC | FCM | 662.5 | 100 tests | RUO | ||
Abbexa | TLR1 | abx270414 | Toll Like Receptor 1 (TLR1) Antibody (FITC) | Human | Monoclonal | Mouse | Toll Like Receptor 1 (TLR1) | FITC | FCM | 475 | 100 tests | RUO | ||
Abbexa | TLR1 | abx270116 | Toll Like Receptor 1 (TLR1) Antibody | Human | Monoclonal | Mouse | Toll Like Receptor 1 (TLR1) | Unconjugated | FCM | 300 | 50 tests | RUO | ||
Abbexa | TLR1 | abx411869 | Toll Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Unconjugated | WB, IHC | 437.5 | 100 µg | Q15399 | RUO | |
Abbexa | TLR1 | abx102056 | Toll Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q15399 | RUO | |
Abbexa | TLR1 | abx370377 | Toll Like Receptor 1 (TLR1) Antibody Pair | Human | Toll Like Receptor 1 (TLR1) | ELISA | 1400 | 5 × 96 tests | RUO | |||||
Abbexa | TLR1 | abx211714 | Toll Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q15399 | RUO | |
Abbexa | TLR1 | abx000950 | Toll-Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | Unconjugated | WB, IHC, IF/ICC | 175 | 20 µl | Q15399 | RUO | |
Abbexa | TLR1 | abx117022 | Toll-Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll-Like Receptor 1 (TLR1) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | Q15399 | RUO | |
Abbexa | TLR1 | abx326826 | Toll Like Receptor 1 (TLR1) Antibody | Human | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Unconjugated | ELISA, IHC | 187.5 | 50 µg | Q15399 | RUO | |
Abbexa | TLR1 | abx130820 | Toll Like Receptor 1 (TLR1) Antibody | Mouse | Polyclonal | Rabbit | Toll Like Receptor 1 (TLR1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9EPQ1 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | TLR1 | abx069356 | Human Toll Like Receptor 1 (TLR1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q15399 | RUO |
Abbexa | TLR1 | abx069357 | Human Toll Like Receptor 1 (TLR1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q15399 | RUO |
Abbexa | TLR1 | abx168804 | Mouse Toll Like Receptor 1 (TLR1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | Q9EPQ1 | RUO |
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