Family main features
The F11 receptor (F11R), also known as Junctional Adhesion Molecule-A (JAM-A), is an integral protein involved in cell-cell adhesion, particularly in the tight junctions of epithelial and endothelial cells. It belongs to the immunoglobulin superfamily and is vital for maintaining barrier integrity in tissues where selective permeability is essential, such as blood-brain, blood-testis, and blood-retina barriers. F11R plays a key role in regulating paracellular permeability, leukocyte transmigration, and cellular signaling, supporting immune responses, hemostasis, and wound healing. It also mediates interactions between platelets, contributing to thrombus formation and platelet aggregation.
Expressed in a variety of tissues, including the endothelium, epithelium, and on platelets, F11R facilitates cell adhesion and communication in multiple physiological processes. Notably, it has been implicated in pathological conditions like inflammation, atherosclerosis, and cancer metastasis, where its dysregulation disrupts cellular integrity and promotes disease progression.
The F11R protein is a type I transmembrane protein and has a complex structure with well-defined domains responsible for its interactions and functions:
Extracellular Domain:
Transmembrane Domain:
Cytoplasmic Tail:
F11R is classified within the immunoglobulin superfamily due to its Ig-like domains. As a member of the junctional adhesion molecule (JAM) family, it is sometimes referred to as JAM-A, distinguishing it from other members, such as JAM-B and JAM-C. JAM family members generally share structural similarities, with conserved Ig domains that support adhesive functions, but each member also has unique roles in specific tissues or cell types. F11R (JAM-A) is specifically involved in epithelial and endothelial barrier functions and platelet aggregation, while other JAM family members play more specialized roles in immune cell trafficking or vascular development.
The primary functions of F11R include cell-cell adhesion, maintenance of tight junctions, and regulation of paracellular permeability. These functions are crucial for maintaining epithelial and endothelial barriers in tissues that require selective permeability, contributing to immune responses and maintaining cellular integrity:
Tight Junction Formation and Maintenance:
Regulation of Paracellular Permeability:
Role in Leukocyte Transmigration:
Platelet Aggregation and Thrombosis:
Signal Transduction:
Dysregulation of F11R has been associated with several pathological conditions, including inflammatory diseases, cardiovascular disorders, and cancer:
Inflammation and Autoimmune Diseases:
Atherosclerosis and Cardiovascular Disease:
Cancer Metastasis:
Infectious Diseases:
The F11R (JAM-A) protein is a type I transmembrane protein belonging to the immunoglobulin superfamily. Characterized by two extracellular Ig-like domains, a transmembrane segment, and a cytoplasmic tail, F11R is critical for cell-cell adhesion in epithelial and endothelial tissues. It functions primarily to maintain tight junction integrity, regulate paracellular permeability, and support immune cell transmigration. Additionally, it plays a role in platelet aggregation and thrombus formation, making it essential for vascular homeostasis and hemostasis.
Clinically, F11R is involved in several disorders, including inflammatory and autoimmune diseases, cardiovascular diseases like atherosclerosis, and cancer metastasis. Its role in maintaining endothelial integrity and regulating immune cell infiltration makes it a promising therapeutic target for managing these conditions. Moreover, as a mediator of platelet aggregation, F11R is a potential target in developing treatments for thrombosis and other cardiovascular complications. The study of F11R provides insights into cellular adhesion mechanisms and its role in disease pathology, with ongoing research focused on therapeutic interventions that modulate its function for disease management.
F11 receptor (F11R)
Junctional adhesion molecule A,JAM,KAT,JAM1,JAMA,JCAM,CD321,PAM-1,Junctional adhesion molecule 1,Platelet F11 receptor
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con F11R - F11 receptor
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Esta página contiene 30 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | F11R | EB0041 | Bovine F11R(Junctional adhesion molecule A) ELISA Kit | bovine | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.156-10ng/ml | 96T | Q9XT56 | RUO | ||
Abbexa | F11R | abx257245 | Cow Junctional Adhesion Molecule 1 / JAM1 (F11R) ELISA Kit | Cow | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.1 ng/ml | 687.5 | 96 tests | RUO | |
Abbexa | F11R | abx493071 | Human Junctional Adhesion Molecule 1 / JAM1 (F11R) CLIA Kit | Human | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.127 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | F11R | abx152073 | Human Junctional Adhesion Molecule 1 / JAM1 (F11R) ELISA Kit | Human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.13 ng/ml | 662.5 | 96 tests | Q9Y624 | RUO |
Abbexa | F11R | abx389235 | Mouse Junctional Adhesion Molecule 1 / JAM1 (F11R) ELISA Kit | Mouse | Plasma | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O88792 | RUO | ||
Abbexa | F11R | abx528936 | Rat Junctional Adhesion Molecule 1 (JAM1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9JHY1 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | F11R | abx270383 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (FITC) | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | FITC | FCM | 575 | 200 tests | RUO | ||
Abbexa | F11R | abx270847 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (PE) | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | PE | FCM | 687.5 | 200 tests | RUO | ||
Abbexa | F11R | abx128588 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | Q9Y624 | RUO | |
Abbexa | F11R | abx173215 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Monoclonal | Mouse | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | F11R | abx336205 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (FITC) | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | FITC | 162.5 | 20 µg | Q9Y624 | RUO | ||
Abbexa | F11R | abx145972 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | F11R | abx430080 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Goat | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | P-ELISA, WB | 387.5 | 200 µl | RUO | ||
Abbexa | F11R | abx333868 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | ELISA, IHC, IF/ICC | 162.5 | 20 µg | Q9Y624 | RUO | |
Abbexa | F11R | abx211232 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9Y624 | RUO | |
Abbexa | F11R | abx336204 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (HRP) | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | HRP | ELISA | 162.5 | 20 µg | Q9Y624 | RUO | |
Abbexa | F11R | abx211231 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | ELISA, WB, IHC | 250 | 50 µl | Q9Y624 | RUO | |
Abbexa | F11R | abx336206 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (Biotin) | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Biotin | ELISA | 162.5 | 20 µg | Q9Y624 | RUO | |
Abbexa | F11R | abx270085 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | FCM | 275 | 50 tests | RUO | ||
Abbexa | F11R | abx270615 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (APC) | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | APC | FCM | 800 | 200 tests | RUO | ||
Abbexa | F11R | abx001153 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | WB, IHC | 175 | 20 µl | Q9Y624 | RUO | |
Abbexa | F11R | abx117076 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | ELISA, WB, IHC | 450 | 100 µl | Q9Y624 | RUO | |
Abbexa | F11R | abx330142 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Human | Polyclonal | Rabbit | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q9Y624 | RUO | |
Abbexa | F11R | abx414071 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Mouse | Monoclonal | Rat | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | IHC, FCM, IP | 462.5 | 250 µg | O88792 | RUO | |
Abbexa | F11R | abx414072 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (Biotin) | Mouse | Monoclonal | Rat | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Biotin | FCM | 400 | 100 µg | O88792 | RUO | |
Abbexa | F11R | abx414073 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody | Mouse | Monoclonal | Rat | Junctional Adhesion Molecule 1 / JAM1 (F11R) | Unconjugated | IHC, FCM, IP | 337.5 | 100 µg | O88792 | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | F11R | abx691294 | Rat Junctional Adhesion Molecule 1 / JAM1 (F11R) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 837.5 | 100 µg | Q9JHY1 | RUO | |
Abbexa | F11R | abx692550 | Rat Junctional Adhesion Molecule 1 / JAM1 (F11R) Protein | Rat | Recombinant | HEK293 cells | SDS-PAGE | 562.5 | 50 µg | Q9JHY1 | RUO | |
Abbexa | F11R | abx168264 | Human Junctional Adhesion Molecule 1 / JAM1 (F11R) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | Q9Y624 | RUO |
Abbexa | F11R | abx260895 | Junctional Adhesion Molecule 1 / JAM1 (F11R) Protein | Recombinant | Unconjugated | SDS-PAGE | 225 | 5 µg | Q9Y624 | RUO |
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