Rat Junctional Adhesion Molecule 1 / JAM1 (F11R) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Rat JAM-A Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat F11R was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | JAM-A |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 49.9 kDa Sequence Fragment: Met1-Gly238 Tag: C-terminal Fc tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 96% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JHY1 |
| Alias | Junctional adhesion molecule A,JAM,KAT,JAM1,JAMA,JCAM,CD321,PAM-1,Junctional adhesion molecule 1,Platelet F11 receptor |
| Background | Protein F11R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The F11 receptor (F11R), also known as Junctional Adhesion Molecule-A (JAM-A), is an integral protein involved in cell-cell adhesion, particularly in the tight junctions of epithelial and endothelial cells. It belongs to the immunoglobulin superfamily and is vital for maintaining barrier integrity in tissues where selective permeability is essential, such as blood-brain, blood-testis, and blood-retina barriers. F11R plays a key role in regulating paracellular permeability, leukocyte transmigration, and cellular signaling, supporting immune responses, hemostasis, and wound healing. It also mediates interactions between platelets, contributing to thrombus formation and platelet aggregation. Expressed in a variety of tissues, including the endothelium, epithelium, and on platelets, F11R facilitates cell adhesion and communication in multiple physiological processes. Notably, it has been implicated in pathological conditions like inflammation, atherosclerosis, and cancer metastasis, where its dysregulation disrupts cellular integrity and promotes disease progression.
Related Products
Bovine F11R (Junctional adhesion molecule A) ELISA Kit
Ver Producto
Recombinant Human F11R
Ver Producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal antibody against F11R. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Ver Producto