Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (APC)
689€ (100 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (APC)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270615
Tested Applications
FCM
Description
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody (APC) is a Rabbit Polyclonal Antibody conjugated to APC against Junctional Adhesion Molecule 1 / JAM1 (F11R) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Junctional Adhesion Molecule 1 / JAM1 (F11R) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 647 Excitation/Emission: 651/660 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | APC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | Junctional adhesion molecule A,JAM,KAT,JAM1,JAMA,JCAM,CD321,PAM-1,Junctional adhesion molecule 1,Platelet F11 receptor |
| Background | Antibody anti-F11R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The F11 receptor (F11R), also known as Junctional Adhesion Molecule-A (JAM-A), is an integral protein involved in cell-cell adhesion, particularly in the tight junctions of epithelial and endothelial cells. It belongs to the immunoglobulin superfamily and is vital for maintaining barrier integrity in tissues where selective permeability is essential, such as blood-brain, blood-testis, and blood-retina barriers. F11R plays a key role in regulating paracellular permeability, leukocyte transmigration, and cellular signaling, supporting immune responses, hemostasis, and wound healing. It also mediates interactions between platelets, contributing to thrombus formation and platelet aggregation. Expressed in a variety of tissues, including the endothelium, epithelium, and on platelets, F11R facilitates cell adhesion and communication in multiple physiological processes. Notably, it has been implicated in pathological conditions like inflammation, atherosclerosis, and cancer metastasis, where its dysregulation disrupts cellular integrity and promotes disease progression.
Productos relacionados
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal antibody against F11R. Tight junctions represent one mode of cell-to-cell adhesion …
Ver producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
Junctional Adhesion Molecule 1 / JAM1 Antibody is a Rabbit Polyclonal against Junctional Adhesion Molecule 1 / JAM1.…
Ver producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal against F11R.…
Ver producto