Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
312€ (60 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx001153
Tested Applications
WB, IHC
Description
F11R Antibody is a Rabbit Polyclonal antibody against F11R. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Junctional Adhesion Molecule 1 / JAM1 (F11R) Immunogen: Recombinant fusion protein corresponding to human F11R |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC-P: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 27 kDa/32 kDa Observed MW: 37 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.01% thiomersal, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9Y624 |
| Gene ID | 50848 |
| NCBI Accession | NP_058642.1 |
| Alias | Junctional adhesion molecule A,JAM,KAT,JAM1,JAMA,JCAM,CD321,PAM-1,Junctional adhesion molecule 1,Platelet F11 receptor |
| Background | Antibody anti-F11R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
The F11 receptor (F11R), also known as Junctional Adhesion Molecule-A (JAM-A), is an integral protein involved in cell-cell adhesion, particularly in the tight junctions of epithelial and endothelial cells. It belongs to the immunoglobulin superfamily and is vital for maintaining barrier integrity in tissues where selective permeability is essential, such as blood-brain, blood-testis, and blood-retina barriers. F11R plays a key role in regulating paracellular permeability, leukocyte transmigration, and cellular signaling, supporting immune responses, hemostasis, and wound healing. It also mediates interactions between platelets, contributing to thrombus formation and platelet aggregation. Expressed in a variety of tissues, including the endothelium, epithelium, and on platelets, F11R facilitates cell adhesion and communication in multiple physiological processes. Notably, it has been implicated in pathological conditions like inflammation, atherosclerosis, and cancer metastasis, where its dysregulation disrupts cellular integrity and promotes disease progression.
Productos relacionados
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal antibody against F11R. Tight junctions represent one mode of cell-to-cell adhesion …
Ver producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
Junctional Adhesion Molecule 1 / JAM1 Antibody is a Rabbit Polyclonal against Junctional Adhesion Molecule 1 / JAM1.…
Ver producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal against F11R.…
Ver producto