Rat Junctional Adhesion Molecule A (F11R) Protein
702€ (50 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Rat Junctional Adhesion Molecule A (F11R) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692550
Tested Applications
SDS-PAGE
Description
Junctional Adhesion Molecule A (F11R) protein is a recombinant Rat protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Junctional Adhesion Molecule A (F11R) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Gly238 Tag: C-terminal His tag |
| Origin | Rat |
| Observed MW | 24.3 kDa |
| Expression | Recombinant |
| Purity | > 23.7+75.2% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9JHY1 |
| Alias | Junctional adhesion molecule A,JAM,KAT,JAM1,JAMA,JCAM,CD321,PAM-1,Junctional adhesion molecule 1,Platelet F11 receptor |
| Background | Protein F11R |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
The F11 receptor (F11R), also known as Junctional Adhesion Molecule-A (JAM-A), is an integral protein involved in cell-cell adhesion, particularly in the tight junctions of epithelial and endothelial cells. It belongs to the immunoglobulin superfamily and is vital for maintaining barrier integrity in tissues where selective permeability is essential, such as blood-brain, blood-testis, and blood-retina barriers. F11R plays a key role in regulating paracellular permeability, leukocyte transmigration, and cellular signaling, supporting immune responses, hemostasis, and wound healing. It also mediates interactions between platelets, contributing to thrombus formation and platelet aggregation. Expressed in a variety of tissues, including the endothelium, epithelium, and on platelets, F11R facilitates cell adhesion and communication in multiple physiological processes. Notably, it has been implicated in pathological conditions like inflammation, atherosclerosis, and cancer metastasis, where its dysregulation disrupts cellular integrity and promotes disease progression.
Productos relacionados
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal antibody against F11R. Tight junctions represent one mode of cell-to-cell adhesion …
Ver producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
Junctional Adhesion Molecule 1 / JAM1 Antibody is a Rabbit Polyclonal against Junctional Adhesion Molecule 1 / JAM1.…
Ver producto
Junctional Adhesion Molecule 1 / JAM1 (F11R) Antibody
F11R Antibody is a Rabbit Polyclonal against F11R.…
Ver producto