Rat Junctional Adhesion Molecule 1 / JAM1 (F11R) Protein
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Description
Rat JAM-A Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat F11R (Q9JHY1) (Met1-Gly238) was expressed with a polyhistidine tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | JAM-A |
| Host | HEK293 cells |
| Origin | Rat |
| Observed MW | Molecular Weight: 24.3 kDa Sequence Fragment: Met1-Gly238 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 23.7+75.2% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9JHY1 |
| Alias | Junctional adhesion molecule A,JAM,KAT,JAM1,JAMA,JCAM,CD321,PAM-1,Junctional adhesion molecule 1,Platelet F11 receptor |
| Background | Protein F11R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The F11 receptor (F11R), also known as Junctional Adhesion Molecule-A (JAM-A), is an integral protein involved in cell-cell adhesion, particularly in the tight junctions of epithelial and endothelial cells. It belongs to the immunoglobulin superfamily and is vital for maintaining barrier integrity in tissues where selective permeability is essential, such as blood-brain, blood-testis, and blood-retina barriers. F11R plays a key role in regulating paracellular permeability, leukocyte transmigration, and cellular signaling, supporting immune responses, hemostasis, and wound healing. It also mediates interactions between platelets, contributing to thrombus formation and platelet aggregation. Expressed in a variety of tissues, including the endothelium, epithelium, and on platelets, F11R facilitates cell adhesion and communication in multiple physiological processes. Notably, it has been implicated in pathological conditions like inflammation, atherosclerosis, and cancer metastasis, where its dysregulation disrupts cellular integrity and promotes disease progression.
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