Family main features
ACER (Alkaline Ceramidase) is an enzyme involved in the metabolism of ceramides, which are lipid molecules found in cell membranes. It plays a crucial role in regulating cellular processes such as apoptosis, cell proliferation, and inflammation by catalyzing the hydrolysis of ceramides into sphingosine and fatty acids. ACER exists in two isoforms, ACER1 and ACER2, localized in different cellular compartments. ACER1 is primarily found in the endoplasmic reticulum, while ACER2 is localized to the lysosomes. Dysregulation of ACER activity has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndrome. Understanding the function of ACER has led to the exploration of its potential as a therapeutic target for treating diseases associated with ceramide imbalance. Modulating ACER activity holds promise for developing novel therapeutic interventions aimed at restoring ceramide homeostasis and mitigating disease progression. Further research into the molecular mechanisms underlying ACER function is essential for elucidating its role in health and disease.
Alkaline ceramidases are membrane-bound enzymes with specific structural features:
The ACER family includes several isoforms, each with unique tissue distribution and function:
ACER enzymes are involved in various physiological processes through their role in sphingolipid metabolism:
ACER enzymes interact with various molecules and pathways:
Alterations in ACER function or expression can lead to various diseases:
Alkaline ceramidases (ACERs) are essential enzymes in sphingolipid metabolism, hydrolyzing ceramides into sphingosine and fatty acids. These enzymes play crucial roles in cell signaling, apoptosis, differentiation, and stress responses. The ACER family includes ACER1, ACER2, and ACER3, each with distinct tissue distribution and functions. Alterations in ACER activity are linked to various diseases, including skin disorders, neurodegenerative diseases, cancer, and metabolic disorders. Understanding the structure, function, and clinical significance of ACERs is essential for developing therapeutic strategies targeting sphingolipid metabolism.
Alkaline Ceramidase 1(ACER1)
ASAH3,ALKCDase1
Alkaline Ceramidase 2(ACER2)
ASAH3L,ALKCDase2
Alkaline Ceramidase 3(ACER3)
APHC,PHCA,PLDECO
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (ELISA Kits, Primary Antibodies) relacionados con ACER - Alkaline Ceramidase
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 15 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACER1 | abx500672 | Human Alkaline ceramidase 1 (ACER1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8TDN7 | RUO | ||
Abbexa | ACER2 | abx500674 | Human Alkaline Ceramidase 2 (ACER2) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | Q5QJU3 | RUO |
Abbexa | ACER3 | abx500676 | Human Alkaline ceramidase 3 (ACER3) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9NUN7 | RUO | ||
Abbexa | ACER3 | abx595477 | Alkaline Ceramidase 3 (ACER3) Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | Q9NUN7 | RUO | |||
Abbexa | ACER1 | abx500673 | Mouse Alkaline ceramidase 1 (ACER1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q8R4X1 | RUO | ||
Abbexa | ACER2 | abx500675 | Mouse Alkaline Ceramidase 2 (ACER2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.07 ng/ml | 687.5 | 96 tests | Q8VD53 | RUO |
Abbexa | ACER3 | abx500677 | Mouse Alkaline ceramidase 3 (ACER3) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | Q9D099 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACER1 | abx323327 | Alkaline Ceramidase 1 (ACER1) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 1 (ACER1) | Unconjugated | ELISA, WB | 187.5 | 50 µg | Q8TDN7 | RUO | |
Abbexa | ACER1 | abx030468 | Alkaline Ceramidase 1 (ACER1) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 1 (ACER1) | Unconjugated | ELISA, WB | 250 | 80 µl | Q8TDN7 | RUO | |
Abbexa | ACER1 | abx037590 | Alkaline Ceramidase 1 (ACER1) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 1 (ACER1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ACER2 | abx037738 | Alkaline Ceramidase 2 (ACER2) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 2 (ACER2) | Unconjugated | ELISA, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ACER2 | abx326246 | Alkaline Ceramidase 2 (ACER2) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 2 (ACER2) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q5QJU3 | RUO | |
Abbexa | ACER3 | abx037548 | Alkaline Ceramidase 3 (ACER3) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 3 (ACER3) | Unconjugated | ELISA, WB | 337.5 | 100 µg | RUO | ||
Abbexa | ACER3 | abx034173 | Alkaline Ceramidase 3 (ACER3) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 3 (ACER3) | Unconjugated | ELISA, WB, FCM | 281.25 | 80 µl | Q9NUN7 | RUO | |
Abbexa | ACER3 | abx326187 | Alkaline Ceramidase 3 (ACER3) Antibody | Human | Polyclonal | Rabbit | Alkaline Ceramidase 3 (ACER3) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | Q9NUN7 | RUO |
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