Mouse Alkaline ceramidase 3 (ACER3) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Alkaline ceramidase 3 (ACER3) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500677
tested applications
ELISA
Description
Mouse Alkaline ceramidase 3 (ACER3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Alkaline ceramidase 3 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alkaline ceramidase 3 (ACER3) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9D099 |
| Gene ID | 66190 |
| Alias | APHC,PHCA,PLDECO |
| Background | Elisa kits for ACER3 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACER3 is an endoplasmic reticulum-localized ceramidase that specializes in hydrolyzing unsaturated ceramides into sphingosine and free fatty acids, optimizing its activity in alkaline pH environments. It is highly expressed in metabolically active and neuronal tissues, such as the brain, liver, and pancreas, where it regulates sphingolipid metabolism and supports processes such as cell survival, apoptosis, autophagy, and stress responses. ACER3 plays a particularly critical role in the nervous system, where sphingolipid homeostasis is essential for neuronal function and survival. Mutations in the ACER3 gene have been associated with hereditary spastic paraplegia, a rare neurodegenerative condition marked by spasticity and progressive weakness. Additionally, ACER3 is implicated in metabolic diseases and cancer, where its regulation of sphingolipids impacts key signaling pathways. By balancing ceramide and sphingosine levels, ACER3 supports cellular adaptation to stress and maintains bioactive lipid equilibrium, making it a potential therapeutic target for neurodegenerative disorders, metabolic dysfunctions, and tumor progression.
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