Mouse Alkaline Ceramidase 2 (ACER2) ELISA Kit
715€ (96 tests)
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935106861
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name
Mouse Alkaline Ceramidase 2 (ACER2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx500675
tested applications
ELISA
Description
Mouse Alkaline Ceramidase 2 (ACER2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Mouse Alkaline Ceramidase 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alkaline Ceramidase 2 (ACER2) |
| Reactivity | Mouse |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8VD53 |
| Gene ID | 230379 |
| Alias | ASAH3L,ALKCDase2 |
| Background | Elisa kits for ACER2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACER2 is a membrane-bound ceramidase that hydrolyzes a variety of ceramide species into sphingosine and fatty acids under alkaline conditions, regulating sphingolipid metabolism across diverse cellular contexts. ACER2 is expressed in numerous tissues, including the liver, brain, immune cells, and lungs, reflecting its broad functional roles. It is critical for generating sphingosine, which is phosphorylated by sphingosine kinases to produce sphingosine-1-phosphate (S1P), a bioactive lipid that mediates cell survival, migration, inflammation, and angiogenesis. ACER2 also contributes to immune system regulation, particularly in lymphocyte trafficking and maintaining vascular integrity. Dysregulation of ACER2 activity has been linked to diseases such as neurodegeneration, metabolic disorders, and cancer progression, where altered ceramide and S1P levels disrupt cell signaling. Emerging evidence highlights its role in apoptotic pathways and chemotherapy resistance in cancer cells, further emphasizing its therapeutic potential as a target for modulating sphingolipid metabolism and associated signaling pathways.
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