Human Alkaline ceramidase 1 (ACER1) ELISA Kit
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Description
Human Alkaline ceramidase 1 (ACER1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Alkaline ceramidase 1 (ACER1) concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alkaline ceramidase 1 (ACER1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8TDN7 |
| OMIM | 613491 |
| Alias | ASAH3,ALKCDase1 |
| Background | Elisa kits for ACER1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACER1 is a ceramidase enzyme that hydrolyzes ceramides into sphingosine and free fatty acids, functioning optimally in alkaline pH conditions. It is primarily localized to the endoplasmic reticulum and is highly expressed in keratinocytes, where it plays a vital role in epidermal differentiation, the formation of the skin barrier, and the regulation of water retention. By modulating ceramide and sphingosine levels, ACER1 influences sphingolipid metabolism and participates in cellular processes such as apoptosis, stress responses, and proliferation. Ceramides are precursors of sphingosine, which is subsequently converted into sphingosine-1-phosphate (S1P), a signaling molecule that regulates cell survival and inflammation. ACER1 is critical for maintaining skin homeostasis, and its dysregulation has been linked to skin disorders, such as psoriasis and impaired wound healing. Beyond its roles in the skin, ACER1 has been implicated in broader inflammatory responses and stress signaling pathways, underlining its importance in maintaining cellular lipid balance and overall tissue health.
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Alkaline Ceramidase 1 (ACER1) Antibody
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).
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ACER1 Antibody is a Rabbit Polyclonal against ACER1.
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