Alkaline Ceramidase 1 (ACER1) Antibody
357.5€ (100 µg)
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Name
Alkaline Ceramidase 1 (ACER1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx037590
Tested Applications
ELISA, WB, IHC
Description
Rabbit Polyclonal against the ACER1 protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Alkaline Ceramidase 1 (ACER1) Immunogen: A peptide corresponding to C-terminal region of human ACER1 protein. |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 46 kDa |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_133492 |
| Alias | ASAH3,ALKCDase1 |
| Background | Antibody anti-ACER1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ACER1 is a ceramidase enzyme that hydrolyzes ceramides into sphingosine and free fatty acids, functioning optimally in alkaline pH conditions. It is primarily localized to the endoplasmic reticulum and is highly expressed in keratinocytes, where it plays a vital role in epidermal differentiation, the formation of the skin barrier, and the regulation of water retention. By modulating ceramide and sphingosine levels, ACER1 influences sphingolipid metabolism and participates in cellular processes such as apoptosis, stress responses, and proliferation. Ceramides are precursors of sphingosine, which is subsequently converted into sphingosine-1-phosphate (S1P), a signaling molecule that regulates cell survival and inflammation. ACER1 is critical for maintaining skin homeostasis, and its dysregulation has been linked to skin disorders, such as psoriasis and impaired wound healing. Beyond its roles in the skin, ACER1 has been implicated in broader inflammatory responses and stress signaling pathways, underlining its importance in maintaining cellular lipid balance and overall tissue health.
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