Alkaline Ceramidase 1 (ACER1) Antibody

Background

ACER1 is a ceramidase enzyme that hydrolyzes ceramides into sphingosine and free fatty acids, functioning optimally in alkaline pH conditions. It is primarily localized to the endoplasmic reticulum and is highly expressed in keratinocytes, where it plays a vital role in epidermal differentiation, the formation of the skin barrier, and the regulation of water retention. By modulating ceramide and sphingosine levels, ACER1 influences sphingolipid metabolism and participates in cellular processes such as apoptosis, stress responses, and proliferation. Ceramides are precursors of sphingosine, which is subsequently converted into sphingosine-1-phosphate (S1P), a signaling molecule that regulates cell survival and inflammation. ACER1 is critical for maintaining skin homeostasis, and its dysregulation has been linked to skin disorders, such as psoriasis and impaired wound healing. Beyond its roles in the skin, ACER1 has been implicated in broader inflammatory responses and stress signaling pathways, underlining its importance in maintaining cellular lipid balance and overall tissue health.