Alkaline Ceramidase 3 (ACER3) Cell ELISA Kit
513.5€ (96 tests)
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935106861
info@markelab.com
name
Alkaline Ceramidase 3 (ACER3) Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595477
tested applications
ELISA
Description
PHCA Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Alkaline Ceramidase 3 (ACER3) |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9NUN7 |
| Gene ID | 55331 |
| Alias | APHC,PHCA,PLDECO |
| Background | Elisa kits for ACER3 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ACER3 is an endoplasmic reticulum-localized ceramidase that specializes in hydrolyzing unsaturated ceramides into sphingosine and free fatty acids, optimizing its activity in alkaline pH environments. It is highly expressed in metabolically active and neuronal tissues, such as the brain, liver, and pancreas, where it regulates sphingolipid metabolism and supports processes such as cell survival, apoptosis, autophagy, and stress responses. ACER3 plays a particularly critical role in the nervous system, where sphingolipid homeostasis is essential for neuronal function and survival. Mutations in the ACER3 gene have been associated with hereditary spastic paraplegia, a rare neurodegenerative condition marked by spasticity and progressive weakness. Additionally, ACER3 is implicated in metabolic diseases and cancer, where its regulation of sphingolipids impacts key signaling pathways. By balancing ceramide and sphingosine levels, ACER3 supports cellular adaptation to stress and maintains bioactive lipid equilibrium, making it a potential therapeutic target for neurodegenerative disorders, metabolic dysfunctions, and tumor progression.
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