Family main features
ACTG encodes gamma-actin, one of the six highly conserved actin isoforms present in eukaryotic cells. Gamma-actin is predominantly found in non-muscle cells and is essential for various cellular processes, including maintenance of the cytoskeleton, cell shape, motility, and intracellular transport. Gamma-actin is critical for cellular integrity and function across a wide range of tissues.Human gamma-actin, with a molecular weight of 41.8 kDa and consisting of 375 amino acids, is widely distributed in the cytoskeletons of various tissues. Within adult striated muscle cells, gamma-actin localizes predominantly to Z-discs and costamere structures, crucial for the transmission and transduction of force in muscle cells. Mutations in the ACTG1 gene, which encodes gamma-actin, have been implicated in several conditions. These include nonsyndromic hearing loss and Baraitser-Winter syndrome. Additionally, there's a noted susceptibility among adolescent patients with ACTG1 mutations to vincristine toxicity. Understanding the role of gamma-actin and its genetic variants is paramount in elucidating the pathophysiology of these conditions and in developing targeted therapeutic interventions.
Gamma-actin has a highly conserved structure characterized by:
Actin proteins are classified into several isoforms based on their tissue distribution:
ACTG specifically refers to the gamma actin isoform, which is ubiquitously expressed in various cell types but predominantly in non-muscle cells.
Gamma-actin plays several critical roles in cellular function:
Gamma-actin interacts with a variety of proteins and molecular pathways:
Alterations or dysregulation of ACTG can lead to several disorders and diseases:
ACTG encodes gamma-actin, a protein essential for the structural integrity and function of non-muscle cells. Gamma-actin forms the cytoskeleton, supports cell motility, facilitates intracellular transport, and regulates cell signaling. Mutations in ACTG1 can lead to hearing loss and other developmental disorders, while its dysregulation is implicated in cancer and other diseases. Understanding the structure, function, interactions, and clinical implications of gamma-actin provides valuable insights into its role in cellular biology and potential therapeutic targets for related diseases.
Actin Gamma 1(ACTG1)
ACT,ACTG,DFNA20,DFNA26
Actin Gamma 2(ACTG2)
ACT,ACTA3,ACTE,ACTL3,ACTSG,MMIHS5
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, Primary Antibodies, CLIA Kits) relacionados con ACTG - Actin Gamma
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 41 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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FineTest | ACTG2 | EB0097 | Bovine ACTgamma2(Actin Gamma 2, Smooth Muscle) ELISA Kit | bovine | Busacar en las instrucciones | Sandwich ELISA, Double Antibody | 0.313-20ng/ml | 96T | Q5E9B5 | RUO | ||
Abbexa | ACTG1 | abx356563 | Chicken Actin, Cytoplasmic 2 (ACTG1) ELISA Kit | Chicken | Serum,Plasma,Other biological fluids | Sandwich | 1.56 pg/ml - 100 pg/ml | 0.94 pg/ml | 662.5 | 96 tests | RUO | |
Abbexa | ACTG2 | abx380026 | Cow Actin Gamma 2, Smooth Muscle (ACTG2) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.064 ng/ml | 700 | 96 tests | Q5E9B5 | RUO |
FineTest | ACTG1 | EH0917 | Human ACTG1(Actin Gamma 1) ELISA Kit | human | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 31.25-2000pg/ml | 96T | P63261 | RUO | ||
Abbexa | ACTG1 | abx195045 | Human Actin Gamma 1 (ACTG1) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 15.6 pg/ml - 1000 pg/ml | 9.38 pg/ml | 618.75 | 96 tests | RUO | |
Abbexa | ACTG1 | abx358589 | Human Actin, Cytoplasmic 2 (ACTG1) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 31.2 pg/ml - 2000 pg/ml | 18.8 pg/ml | 525 | 96 tests | P63261 | RUO |
Abbexa | ACTG2 | abx150529 | Human Actin, Gamma 2, Smooth Muscle (ACTG2) ELISA Kit | Human | Tissue homogenates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.06 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | ACTG2 | abx492669 | Human Actin gamma 2, Smooth Muscle (ACTg2) CLIA Kit | Human | Tissue homogenates and other biological fluids. | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.053 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACTG1 | abx500919 | Mouse Actin, cytoplasmic 2 (ACTG1) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P63260 | RUO | ||
Abbexa | ACTG2 | abx388493 | Mouse Actin, Gamma 2, Smooth Muscle (ACTG2) ELISA Kit | Mouse | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 78 pg/ml - 5000 pg/ml | < 46.9 pg/ml | 687.5 | 96 tests | P63268 | RUO |
Abbexa | ACTG1 | abx500920 | Rat Actin, Cytoplasmic 2 (ACTG1) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | P63259 | RUO | ||
Abbexa | ACTG2 | abx390922 | Rat Actin, Gamma 2, Smooth Muscle (ACTG2) ELISA Kit | Rat | Tissue homogenates,Cell lysates,Other biological fluids | Sandwich | 0.156 ng/ml - 10 ng/ml | < 0.094 ng/ml | 687.5 | 96 tests | P63269 | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACTG1 | abx314388 | Actin Gamma 1 (ACTG1) Antibody (Biotin) | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Biotin | ELISA | 162.5 | 20 µg | P63261 | RUO | |
Abbexa | ACTG1 | abx122377 | Actin Gamma 1 (ACTG1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ACTG1 | abx175223 | Actin Gamma 1 (ACTg1) Antibody | Human | Polyclonal | Guinea pig | Actin Gamma 1 (ACTg1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ACTG1 | abx128475 | Actin Gamma 1 (ACTg1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTg1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ACTG1 | abx302444 | Actin Gamma 1 (ACTG1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Unconjugated | ELISA, WB, IHC, IF/ICC | 162.5 | 20 µg | P63261 | RUO | |
Abbexa | ACTG1 | abx032855 | Actin Gamma 1 (ACTG1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Unconjugated | ELISA, WB, IF/ICC, FCM | 281.25 | 80 µl | P63261 | RUO | |
Abbexa | ACTG1 | abx101121 | Actin Gamma 1 (ACTg1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTg1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ACTG1 | abx314387 | Actin Gamma 1 (ACTG1) Antibody (FITC) | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | FITC | 162.5 | 20 µg | P63261 | RUO | ||
Abbexa | ACTG1 | abx314386 | Actin Gamma 1 (ACTG1) Antibody (HRP) | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | HRP | ELISA | 162.5 | 20 µg | P63261 | RUO | |
Abbexa | ACTG1 | abx038447 | ACTG Antibody | Human | Polyclonal | Rabbit | ACTG | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ACTG1 | abx110773 | Actin Gamma 1 (ACTG1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Unconjugated | ELISA, WB | 612.5 | 100 µl | P63261 | RUO | |
Abbexa | ACTG1 | abx242247 | Actin Gamma 1 (ACTG1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Unconjugated | ELISA, WB | 250 | 50 µl | P63261 | RUO | |
Abbexa | ACTG1 | abx214699 | Actin Gamma 1 (ACTG1) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 1 (ACTG1) | Unconjugated | ELISA, WB | 250 | 50 µl | P63261 | RUO | |
Abbexa | ACTG2 | abx171060 | Actin Gamma 2, Smooth Muscle (ACTg2) Antibody | Human | Monoclonal | Mouse | Actin Gamma 2, Smooth Muscle (ACTg2) | Unconjugated | WB, IHC, IF/ICC | 750 | 1 ml | RUO | ||
Abbexa | ACTG2 | abx306543 | Actin, Gamma 2, Smooth Muscle (ACTG2) Antibody (FITC) | Human | Polyclonal | Rabbit | Actin, Gamma 2, Smooth Muscle (ACTG2) | FITC | 162.5 | 20 µg | P63267 | RUO | ||
Abbexa | ACTG2 | abx128145 | Actin Gamma 2, Smooth Muscle (ACTg2) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 2, Smooth Muscle (ACTg2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | P63267 | RUO | |
Abbexa | ACTG2 | abx306542 | Actin, Gamma 2, Smooth Muscle (ACTG2) Antibody (HRP) | Human | Polyclonal | Rabbit | Actin, Gamma 2, Smooth Muscle (ACTG2) | HRP | ELISA | 162.5 | 20 µg | P63267 | RUO | |
Abbexa | ACTG2 | abx306544 | Actin, Gamma 2, Smooth Muscle (ACTG2) Antibody (Biotin) | Human | Polyclonal | Rabbit | Actin, Gamma 2, Smooth Muscle (ACTG2) | Biotin | ELISA | 162.5 | 20 µg | P63267 | RUO | |
Abbexa | ACTG2 | abx027450 | Actin, Gamma 2, Smooth Muscle (ACTG2) Antibody | Human | Polyclonal | Rabbit | Actin, Gamma 2, Smooth Muscle (ACTG2) | Unconjugated | ELISA, WB, IHC | 281.25 | 80 µl | P63267 | RUO | |
Abbexa | ACTG2 | abx175227 | Actin Gamma 2, Smooth Muscle (ACTg2) Antibody | Human | Polyclonal | Guinea pig | Actin Gamma 2, Smooth Muscle (ACTg2) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ACTG2 | abx306541 | Actin, Gamma 2, Smooth Muscle (ACTG2) Antibody | Human | Polyclonal | Rabbit | Actin, Gamma 2, Smooth Muscle (ACTG2) | Unconjugated | ELISA, WB, IHC | 162.5 | 20 µg | P63267 | RUO | |
Abbexa | ACTG2 | abx122376 | Actin, Gamma 2, Smooth Muscle (ACTG2) Antibody | Human | Polyclonal | Rabbit | Actin, Gamma 2, Smooth Muscle (ACTG2) | Unconjugated | ELISA, WB, IHC | 337.5 | 100 µg | RUO | ||
Abbexa | ACTG2 | abx013018 | Actin Gamma 2 (Actg2) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 2 (Actg2) | Unconjugated | WB, IHC | 43.75 | 10 µg | P63267 | RUO | |
Abbexa | ACTG2 | abx329445 | Actin Gamma 2, Enteric Smooth Muscle (ACTG2) Antibody | Human | Polyclonal | Rabbit | Actin Gamma 2, Enteric Smooth Muscle (ACTG2) | Unconjugated | ELISA, WB, IHC, IF/ICC | 187.5 | 50 µg | P63267 | RUO | |
Abbexa | ACTG1 | abx175224 | Actin Gamma 1 (ACTg1) Antibody | Mouse | Polyclonal | Rabbit | Actin Gamma 1 (ACTg1) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACTG1 | abx065111 | Human Actin Gamma 1 (ACTg1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P63261 | RUO |
Abbexa | ACTG1 | abx065110 | Human Actin Gamma 1 (ACTg1) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | P63261 | RUO |
Abbexa | ACTG1 | abx652162 | Mouse Actin Gamma 1 (ACTg1) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | Q4KL81 | RUO |
Abbexa | ACTG2 | abx166595 | Human Actin Gamma 2, Smooth Muscle (ACTg2) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 212.5 | 10 µg | RUO |
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