Actin Gamma 1 (ACTg1) Antibody
273€ (100 µl)
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935106861
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name
Actin Gamma 1 (ACTg1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx175223
tested applications
WB, IHC, IF/ICC
Description
Actin Gamma 1 (ACTg1) Antibody is a Guinea pig Polyclonal antibody against Actin Gamma 1 (ACTg1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Actin Gamma 1 (ACTg1) |
| Host | Guinea pig |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACT,ACTG,DFNA20,DFNA26 |
| Background | Antibody anti-ACTG1 |
| Status | RUO |
Descripción
ACTG1 encodes gamma-actin, a key cytoskeletal protein found primarily in non-muscle cells where it contributes to the maintenance of the cytoskeleton's integrity and dynamics. As a highly conserved isoform of actin, ACTG1 is crucial for cellular processes such as migration, adhesion, intracellular trafficking, and division. It is predominantly expressed in epithelial cells and is involved in the organization of cell junctions and maintenance of tissue structure. Mutations in the ACTG1 gene have been linked to autosomal dominant progressive hearing loss (DFNA20/26) due to its role in maintaining the structural integrity of stereocilia in the cochlea. Beyond its structural role, ACTG1 interacts with a range of actin-binding proteins, regulating the assembly and disassembly of actin filaments in response to cellular signaling. Dysregulation or mutations in ACTG1 are also associated with cancer progression and metastasis, highlighting its role in cell motility and invasion. Its ubiquitous presence and functional versatility underscore its critical role in both cellular architecture and dynamic cellular processes.
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Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, is a cytoplasmic actin found in nonmuscle cells.
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