Actin, Gamma-Enteric Smooth Muscle (ACTG2) Antibody
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Description
Actin, Gamma-Enteric Smooth Muscle (ACTG2) Antibody is a Rabbit polyclonal against Actin, Gamma-Enteric Smooth Muscle (ACTG2).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Actin, Gamma-Enteric Smooth Muscle (ACTG2) Immunogen: The antiserum was produced against a synthesized peptide derived from Human Actin, Gamma-Enteric Smooth Muscle (ACTG2). |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | ELISA: 1/20000, WB: 1/500 - 1/3000, IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C for up to 1 year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P63267 |
| Alias | ACT,ACTA3,ACTE,ACTL3,ACTSG,MMIHS5 |
| Background | Antibody anti-ACTG2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
ACTG2 encodes gamma-actin, a highly conserved cytoskeletal protein primarily expressed in smooth muscle cells. It plays a vital role in maintaining the structure and contractility of smooth muscle tissues in organs such as the gastrointestinal tract and bladder. As part of the actin family, ACTG2 contributes to cellular processes like motility, intracellular transport, and mechanical force generation. Mutations in ACTG2 have been associated with disorders such as visceral myopathy, characterized by severe dysfunction of smooth muscle contractility. This protein is essential for the proper functioning of muscle-based physiological activities and demonstrates high evolutionary conservation due to its critical cellular roles.
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Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 2, encoded by this gene, is a smooth muscle actin found in enteric tissues.
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