Human Actin Gamma 1 (ACTG1) CLIA Kit

Product specifications

CLIA Kits

Actin Gamma 1 (ACTG1)

Human

Chemiluminescent

Quantitative

Sandwich

15.6 pg/ml - 1000 pg/ml

9.38 pg/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

Lyophilized

CLIA

Serum, plasma and other biological fluids.

Shipped within 5-12 working days.

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

ACT,ACTG,DFNA20,DFNA26

CLIA Kits ACTG1

RUO

The validity for this kit is 6 months.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

ACTG1 encodes gamma-actin, a key cytoskeletal protein found primarily in non-muscle cells where it contributes to the maintenance of the cytoskeleton's integrity and dynamics. As a highly conserved isoform of actin, ACTG1 is crucial for cellular processes such as migration, adhesion, intracellular trafficking, and division. It is predominantly expressed in epithelial cells and is involved in the organization of cell junctions and maintenance of tissue structure. Mutations in the ACTG1 gene have been linked to autosomal dominant progressive hearing loss (DFNA20/26) due to its role in maintaining the structural integrity of stereocilia in the cochlea. Beyond its structural role, ACTG1 interacts with a range of actin-binding proteins, regulating the assembly and disassembly of actin filaments in response to cellular signaling. Dysregulation or mutations in ACTG1 are also associated with cancer progression and metastasis, highlighting its role in cell motility and invasion. Its ubiquitous presence and functional versatility underscore its critical role in both cellular architecture and dynamic cellular processes.

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Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. Actin, gamma 1, is a cytoplasmic actin found in nonmuscle cells.

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