Family main features
Acetyl Coenzyme A Carboxylase (ACAC) is a crucial enzyme in fatty acid metabolism, playing a key role in the regulation of fatty acid synthesis. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first committed step in fatty acid biosynthesis. ACACA (Alpha), also known as ACC1, is primarily found in the cytoplasm. It plays a central role in lipogenesis (the synthesis of fatty acids) by producing malonyl-CoA, which serves as a precursor for fatty acid synthesis and as an inhibitor of fatty acid oxidation. ACACB (Beta), also known as ACC2, is primarily located in mitochondria, where it regulates fatty acid oxidation. Unlike ACACA, which generates malonyl-CoA in the cytoplasm for fatty acid synthesis, ACACB produces malonyl-CoA in mitochondria, where it acts as an allosteric inhibitor of carnitine palmitoyltransferase 1 (CPT1). CPT1 is a key enzyme involved in the transport of fatty acids into the mitochondria for oxidation. By inhibiting CPT1, ACACB helps to regulate fatty acid oxidation based on cellular energy needs. Both isoforms of Acetyl-CoA Carboxylase are subject to complex regulation at multiple levels, including transcriptional, post-translational, and allosteric regulation, to ensure that fatty acid synthesis and oxidation are coordinated according to cellular energy demands and nutritional status.
Both ACACA and ACACB share common structural features essential for their function:
ACAC enzymes are classified into two main isoforms:
ACAC enzymes have pivotal roles in lipid metabolism:
ACAC enzymes interact with various molecules and proteins:
Dysregulation of ACAC enzymes is associated with several metabolic diseases:
Acetyl Coenzyme A Carboxylase (ACAC) is a key enzyme in fatty acid metabolism, with two main isoforms, ACACA and ACACB, that regulate fatty acid synthesis and oxidation. These enzymes catalyze the formation of malonyl-CoA, a crucial metabolite in lipid metabolism. ACAC enzymes are regulated by nutritional and hormonal signals, ensuring proper lipid homeostasis. Dysregulation of ACAC activity is implicated in metabolic disorders such as obesity, diabetes, cardiovascular diseases, and cancer, highlighting their importance in maintaining metabolic balance and health.
Acetyl Coenzyme A Carboxylase Alpha(ACACA)
ACACD,ACACalpha,ACC,ACC1,ACCA
Acetyl Coenzyme A Carboxylase Beta (ACACB)
ACACbeta, ACC-beta, ACC2, ACCB, ACCbeta
En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Proteins and Peptides, ELISA Kits, CLIA Kits, Primary Antibodies) relacionados con ACAC - Acetyl Coenzyme A Carboxylase Alpha/Beta
Se muestran ordenados por categorías para poder comparar cómodamente sus características principales. Esta tabla, que contiene un enlace con la ficha de cada producto, es exportable a Excel.
Esta página contiene 29 reactivos de las marcas (Abbexa, FineTest) que se corresponden con tu busqueda
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provider | Code | reference | name | reactivity | sample type | assay type | test range | sensitivity | price | size 1 | uniprot id | status |
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Abbexa | ACACA | abx516216 | Cow Acetyl Coenzyme A Carboxylase Alpha (ACACA) ELISA Kit | Cow | Tissue homogenates,Cell lysates,Other biological fluids | 78 pg/ml - 5000 pg/ml | 687.5 | 96 tests | Q9TTS3 | RUO | ||
Abbexa | ACACA | abx492587 | Human Acetyl Coenzyme A Carboxylase alpha (ACACA) CLIA Kit | Human | Serum, plasma and other biological fluids. | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.09 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACACA | abx500581 | Human Acetyl-CoA carboxylase 2 (ACACB) ELISA Kit | Human | Tissue homogenates,Cell lysates,Other biological fluids | 0.156 ng/ml - 10 ng/ml | 687.5 | 96 tests | O00763 | RUO | ||
Abbexa | ACACA | abx575326 | Human Acetyl Coenzyme A Carboxylase Alpha (ACACA) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 1.56 ng/ml - 100 ng/ml | 0.94 ng/ml | 556.25 | 96 tests | Q13085, O00763 | RUO |
Abbexa | ACACA | abx150517 | Human Acetyl Coenzyme A Carboxylase Alpha (ACACA) ELISA Kit | Human | Serum,Plasma,Other biological fluids | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.09 ng/ml | 662.5 | 96 tests | RUO | |
Abbexa | ACACA | abx595013 | Acetyl-CoA Carboxylase 1 (ACACA) Cell ELISA Kit | Human | Cell ELISA | 493.75 | 96 tests | Q13085 | RUO | |||
FineTest | ACACA | EM1945 | Mouse Acaca (Acetyl-CoA carboxylase) ELISA Kit | mouse | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | Q5SWU9 | RUO | ||
Abbexa | ACACA | abx153583 | Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACA) ELISA Kit | Mouse | Tissue homogenates,Other biological fluids | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.12 ng/ml | 618.75 | 96 tests | RUO | |
Abbexa | ACACA | abx492588 | Mouse Acetyl Coenzyme A Carboxylase alpha (ACACA) CLIA Kit | Mouse | Tissue homogenates, cell lysates and other biological fluids. | Sandwich | 0.312 ng/ml - 20 ng/ml | < 0.117 ng/ml | 812.5 | 96 tests | RUO | |
FineTest | ACACA | ER0494 | Rat Acaca(Acetyl-CoA carboxylase 1) ELISA Kit | rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich ELISA, Double Antibody | 15.625-1000pg/ml | 96T | P11497 | RUO | ||
Abbexa | ACACA | abx492589 | Rat Acetyl Coenzyme A Carboxylase alpha (ACACA) CLIA Kit | Rat | Serum, plasma, tissue homogenates and other biological fluids. | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.34 ng/ml | 812.5 | 96 tests | RUO | |
Abbexa | ACACA | abx155130 | Rat Acetyl Coenzyme A Carboxylase Alpha (ACACA) ELISA Kit | Rat | Serum,Plasma,Tissue homogenates,Other biological fluids | Sandwich | 3.12 ng/ml - 200 ng/ml | < 1.18 ng/ml | 618.75 | 96 tests | RUO |
provider | Code | reference | name | reactivity | clonality | host | immunogen target | isotype | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACACB | abx432268 | Acetyl Coenzyme A Carboxylase Beta (ACACB) Antibody | Polyclonal | Goat | Acetyl Coenzyme A Carboxylase Beta (ACACB) | Unconjugated | P-ELISA | 250 | 200 µl | RUO | |||
Abbexa | ACACA | abx029314 | Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha (ACACA) | Unconjugated | ELISA, WB | 281.25 | 80 µl | Q13085 | RUO | |
Abbexa | ACACA | abx175208 | Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha (ACACA) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO | ||
Abbexa | ACACA | abx332863 | Acetyl Coenzyme A Carboxylase Alpha Phospho-Ser79 (ACACA pS79) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha Phospho-Ser79 (ACACA pS79) | Unconjugated | 412.5 | 100 µl | Q13085 | RUO | ||
Abbexa | ACACA | abx328924 | Acetyl Coenzyme A Carboxylase Alpha Phospho-Ser80 (ACACA pS80) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha Phospho-Ser80 (ACACA pS80) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q13085 | RUO | |
Abbexa | ACACA | abx328923 | Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha (ACACA) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q13085 | RUO | |
Abbexa | ACACA | abx328186 | Acetyl Coenzyme A Carboxylase Alpha Phospho-Ser80 (ACACA pS80) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha Phospho-Ser80 (ACACA pS80) | Unconjugated | ELISA, WB, IHC | 187.5 | 50 µg | Q13085 | RUO | |
Abbexa | ACACB | abx431001 | Acetyl Coenzyme A Carboxylase Beta (Acacb) Antibody | Human | Polyclonal | Goat | Acetyl Coenzyme A Carboxylase Beta (Acacb) | Unconjugated | P-ELISA, IHC | 387.5 | 200 µl | RUO | ||
Abbexa | ACACB | abx130598 | Acetyl Coenzyme A Carboxylase Beta (ACACb) Antibody | Human | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Beta (ACACb) | Unconjugated | WB, IHC, IF/ICC | 275 | 100 µl | RUO | ||
Abbexa | ACACB | abx432267 | Acetyl Coenzyme A Carboxylase Beta (ACACB) Antibody | Human | Polyclonal | Goat | Acetyl Coenzyme A Carboxylase Beta (ACACB) | Unconjugated | P-ELISA | 250 | 200 µl | RUO | ||
Abbexa | ACACA | abx175209 | Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody | Mouse | Polyclonal | Rabbit | Acetyl Coenzyme A Carboxylase Alpha (ACACA) | Unconjugated | WB, IHC, IF/ICC | 262.5 | 100 µl | RUO |
provider | Code | reference | name | origin | expression | host | conjugation | tested applications | price | size 1 | uniprot id | status |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Abbexa | ACACA | abx652362 | Rat Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein | Rat | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 2475 | 1 mg | RUO | |
Abbexa | ACACA | abx652360 | Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
Abbexa | ACACA | abx652359 | Human Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | RUO | |
Abbexa | ACACA | abx652361 | Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 225 | 10 µg | RUO | |
Abbexa | ACACB | abx652363 | Mouse Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein | Mouse | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 187.5 | 10 µg | E9Q4Z2 | RUO |
Abbexa | ACACB | abx650414 | Human Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein | Human | Recombinant | E. coli | Unconjugated | WB, SDS-PAGE | 200 | 10 µg | O00763 | RUO |
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