Acetyl Coenzyme A Carboxylase Beta (ACACb) Antibody
286€ (100 µl)
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935106861
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name
Acetyl Coenzyme A Carboxylase Beta (ACACb) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx130598
tested applications
WB, IHC, IF/ICC
Description
ACACb Antibody is a Rabbit Polyclonal against ACACb.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Acetyl Coenzyme A Carboxylase Beta (ACACb) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACACbeta, ACC-beta, ACC2, ACCB, ACCbeta |
| Background | Antibody anti-ACACB |
| Status | RUO |
Descripción
Acetyl Coenzyme A Carboxylase Beta (ACACB) is a mitochondrial enzyme involved in the regulation of fatty acid oxidation. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which acts as an allosteric inhibitor of carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for mitochondrial fatty acid uptake and oxidation. ACACB is primarily expressed in tissues with high fatty acid oxidation rates, such as skeletal muscle, heart, and liver, and plays a key role in energy homeostasis by modulating the balance between fatty acid synthesis and degradation. Mutations or dysregulation of ACACB can lead to altered lipid metabolism and are associated with conditions such as insulin resistance, obesity, and cardiovascular diseases. ACACB is also a promising target for therapeutic intervention in metabolic disorders, with inhibitors designed to promote fatty acid oxidation and reduce lipid accumulation in obesity and type 2 diabetes.
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