Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein
208€ (10 µg)
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Name
Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx652360
Tested Applications
WB, SDS-PAGE
Description
Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACa) Protein is a recombinant Mouse protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Acetyl Coenzyme A Carboxylase Alpha (ACACA) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Pro1184-Phe1351 Tag: N-terminal His tag |
| Origin | Mouse |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 23.0 kDa Observed MW: 26 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| Alias | ACACD,ACACalpha,ACC,ACC1,ACCA |
| Background | Protein ACACA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Acetyl Coenzyme A Carboxylase Alpha (ACACA) is a cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a critical step in fatty acid biosynthesis. ACACA is the rate-limiting enzyme in the synthesis of long-chain fatty acids and plays a central role in lipogenesis. It is highly expressed in lipogenic tissues such as the liver and adipose tissue and is tightly regulated by phosphorylation, dephosphorylation, and allosteric effectors like citrate and palmitoyl-CoA. Dysregulation of ACACA activity contributes to metabolic disorders such as obesity, type 2 diabetes, and fatty liver disease, where excessive lipogenesis exacerbates lipid accumulation. In cancer, ACACA is upregulated to support the enhanced lipid biosynthesis required for rapid tumor cell proliferation, making it a potential therapeutic target. Small-molecule inhibitors of ACACA are being developed to treat metabolic diseases and cancer by reducing de novo fatty acid synthesis.
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