Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody
221€ (50 µg)
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Name
Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx328923
Tested Applications
ELISA, WB, IHC
Description
ACACA Antibody is a Rabbit Polyclonal against ACACA.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Acetyl Coenzyme A Carboxylase Alpha (ACACA) Immunogen: Synthesized peptide derived from human ACCα around the non-phosphorylation site of S80. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | ELISA: 1/5000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13085 |
| Gene ID | 31 |
| Alias | ACACD,ACACalpha,ACC,ACC1,ACCA |
| Background | Antibody anti-ACACA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Acetyl Coenzyme A Carboxylase Alpha (ACACA) is a cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a critical step in fatty acid biosynthesis. ACACA is the rate-limiting enzyme in the synthesis of long-chain fatty acids and plays a central role in lipogenesis. It is highly expressed in lipogenic tissues such as the liver and adipose tissue and is tightly regulated by phosphorylation, dephosphorylation, and allosteric effectors like citrate and palmitoyl-CoA. Dysregulation of ACACA activity contributes to metabolic disorders such as obesity, type 2 diabetes, and fatty liver disease, where excessive lipogenesis exacerbates lipid accumulation. In cancer, ACACA is upregulated to support the enhanced lipid biosynthesis required for rapid tumor cell proliferation, making it a potential therapeutic target. Small-molecule inhibitors of ACACA are being developed to treat metabolic diseases and cancer by reducing de novo fatty acid synthesis.
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