Human Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein
208€ (10 µg)
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935106861
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name
Human Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx650414
tested applications
WB, SDS-PAGE
Description
Human ACACb Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Acetyl Coenzyme A Carboxylase Beta (ACACb) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 65.8 kDa Observed MW (SDS-PAGE): 65 kDa Concentration: Prior to lyophilization: 400 µg/ml Sequence Fragment: Met217-Val775 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 80% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 100 mM NaHCO<sub>3</sub>, 500 mM NaCl, pH 8.3, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00763 |
| Alias | ACACbeta, ACC-beta, ACC2, ACCB, ACCbeta |
| Background | Protein ACACB |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Acetyl Coenzyme A Carboxylase Beta (ACACB) is a mitochondrial enzyme involved in the regulation of fatty acid oxidation. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which acts as an allosteric inhibitor of carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for mitochondrial fatty acid uptake and oxidation. ACACB is primarily expressed in tissues with high fatty acid oxidation rates, such as skeletal muscle, heart, and liver, and plays a key role in energy homeostasis by modulating the balance between fatty acid synthesis and degradation. Mutations or dysregulation of ACACB can lead to altered lipid metabolism and are associated with conditions such as insulin resistance, obesity, and cardiovascular diseases. ACACB is also a promising target for therapeutic intervention in metabolic disorders, with inhibitors designed to promote fatty acid oxidation and reduce lipid accumulation in obesity and type 2 diabetes.
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