Mouse Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein

Este producto es parte de ACAC - Acetyl Coenzyme A Carboxylase Alpha/Beta
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195€ (10 µg)

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935106861
info@markelab.com
name
Mouse Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652363
tested applications
WB, SDS-PAGE

Description

Mouse Acetyl Coenzyme A Carboxylase Beta (ACACb) Protein is a Recombinant Mouse protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Acetyl Coenzyme A Carboxylase Beta (ACACb)
Host
E. coli
Origin
Mouse
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 39.8 kDa  Observed MW (SDS-PAGE): 40 kDa
Concentration: Prior to lyophilization: 700 µg/ml
Sequence Fragment: Pro2019-Arg2335
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
E9Q4Z2
Alias
ACACbeta, ACC-beta, ACC2, ACCB, ACCbeta
Background
Protein ACACB
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Acetyl Coenzyme A Carboxylase Beta (ACACB) is a mitochondrial enzyme involved in the regulation of fatty acid oxidation. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which acts as an allosteric inhibitor of carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme for mitochondrial fatty acid uptake and oxidation. ACACB is primarily expressed in tissues with high fatty acid oxidation rates, such as skeletal muscle, heart, and liver, and plays a key role in energy homeostasis by modulating the balance between fatty acid synthesis and degradation. Mutations or dysregulation of ACACB can lead to altered lipid metabolism and are associated with conditions such as insulin resistance, obesity, and cardiovascular diseases. ACACB is also a promising target for therapeutic intervention in metabolic disorders, with inhibitors designed to promote fatty acid oxidation and reduce lipid accumulation in obesity and type 2 diabetes.

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