Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody
273€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Acetyl Coenzyme A Carboxylase Alpha (ACACA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx175209
tested applications
WB, IHC, IF/ICC
Description
Acetyl Coenzyme A Carboxylase Alpha (ACACa) Antibody is a Rabbit Polyclonal antibody against Acetyl Coenzyme A Carboxylase Alpha (ACACa).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Acetyl Coenzyme A Carboxylase Alpha (ACACA) Immunogen: abx652361 - Recombinant Acetyl Coenzyme A Carboxylase Alpha (ACACa) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | ACACD,ACACalpha,ACC,ACC1,ACCA |
| Background | Antibody anti-ACACA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Acetyl Coenzyme A Carboxylase Alpha (ACACA) is a cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, a critical step in fatty acid biosynthesis. ACACA is the rate-limiting enzyme in the synthesis of long-chain fatty acids and plays a central role in lipogenesis. It is highly expressed in lipogenic tissues such as the liver and adipose tissue and is tightly regulated by phosphorylation, dephosphorylation, and allosteric effectors like citrate and palmitoyl-CoA. Dysregulation of ACACA activity contributes to metabolic disorders such as obesity, type 2 diabetes, and fatty liver disease, where excessive lipogenesis exacerbates lipid accumulation. In cancer, ACACA is upregulated to support the enhanced lipid biosynthesis required for rapid tumor cell proliferation, making it a potential therapeutic target. Small-molecule inhibitors of ACACA are being developed to treat metabolic diseases and cancer by reducing de novo fatty acid synthesis.
Related Products
Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACA) Protein
Mouse Acetyl Coenzyme A Carboxylase Alpha (ACACa) Protein is a recombinant Mouse protein expressed in E. coli.
Ver Producto