VSIG - V-set and immunoglobulin domain containing | Elisa - Clia - Antibody - Protein

Family main features

Background

The VSIG (V-set and Immunoglobulin domain-containing) family encompasses a group of proteins that are characterized by the presence of immunoglobulin (Ig) domains. These proteins play significant roles in various cellular processes, including cell adhesion, immune response, and signal transduction. The VSIG family is part of the larger immunoglobulin superfamily (IgSF), which is known for its involvement in the immune system and intercellular interactions.

VSIG proteins are expressed in various tissues and cells, including epithelial cells, lymphocytes, and other immune cells. Their expression patterns and functional roles are often linked to their capacity to mediate cell-cell interactions, which are crucial for maintaining tissue integrity and facilitating immune surveillance.


Protein Structure

VSIG proteins typically feature the following structural components:

  • Extracellular Region: This region consists of one or more Ig-like domains, which are responsible for mediating interactions with other proteins and cell surface receptors. These domains are critical for the protein’s function in cell adhesion and signal transduction.
  • Transmembrane Domain: This hydrophobic segment anchors the protein in the cell membrane, facilitating its role as a receptor or adhesion molecule.
  • Cytoplasmic Tail: The intracellular portion often contains motifs that are involved in signal transduction, allowing the protein to relay signals from the extracellular environment to the cell’s interior.

The Ig-like domains within VSIG proteins can vary in number and type, contributing to the diversity of functions and interactions these proteins can mediate.


Classification and Subtypes

The VSIG family includes several members, each with distinct expression patterns and functional roles. Key subtypes include:

  1. VSIG1: Primarily expressed in the stomach and testis, VSIG1 is involved in cell adhesion and has been implicated in the maintenance of epithelial integrity.
  2. VSIG2: Also known as CTLA-4 ligand, VSIG2 is expressed in the thymus and other tissues. It plays a role in immune regulation by interacting with CTLA-4 on T cells.
  3. VSIG3: This protein is expressed in the brain and has been linked to neuronal development and function.
  4. VSIG4: Also known as CRIg (complement receptor of the Ig superfamily), VSIG4 is expressed on macrophages and is involved in the regulation of the complement system and immune responses.


Function and Biological Significance

VSIG proteins are involved in a variety of cellular functions, including:

  • Cell Adhesion: VSIG proteins mediate homophilic and heterophilic interactions that are essential for maintaining tissue architecture and facilitating cell migration. These interactions are crucial for processes such as epithelial cell integrity and neuronal networking.
  • Immune Regulation: Some VSIG proteins, such as VSIG2 and VSIG4, play significant roles in modulating immune responses. VSIG2 interacts with CTLA-4 to regulate T cell activation, while VSIG4 acts as an immune checkpoint by inhibiting complement activation and promoting the clearance of pathogens and apoptotic cells.
  • Signal Transduction: The cytoplasmic tails of VSIG proteins often contain motifs that participate in intracellular signaling pathways, allowing these proteins to influence cellular responses to external stimuli.


Clinical Issues

Dysregulation of VSIG proteins has been associated with various diseases and pathological conditions:

  • Cancer: Altered expression of VSIG proteins has been observed in several types of cancer. For example, VSIG1 expression is downregulated in gastric cancer, suggesting a potential role in tumor suppression. Conversely, overexpression of VSIG4 has been linked to the promotion of tumor immune evasion, making it a potential target for cancer immunotherapy.
  • Autoimmune Diseases: Given their role in immune regulation, aberrant VSIG protein function can contribute to the development of autoimmune diseases. For instance, dysregulated VSIG4 activity has been implicated in conditions such as systemic lupus erythematosus (SLE), where it may contribute to impaired clearance of immune complexes.
  • Neurodevelopmental Disorders: VSIG3, which is expressed in the brain, has been associated with neurodevelopmental and psychiatric disorders. Its precise role in these conditions is an area of ongoing research.


Summary

The VSIG family of proteins plays diverse and crucial roles in cell adhesion, immune regulation, and signal transduction. Their expression and function in various tissues underscore their importance in maintaining cellular and tissue integrity, as well as in regulating immune responses. Dysregulation of VSIG proteins is linked to a range of diseases, including cancer, autoimmune disorders, and neurodevelopmental conditions, highlighting their potential as therapeutic targets. Understanding the intricate roles and mechanisms of VSIG proteins continues to be a significant area of research, with implications for developing novel treatments for various pathologies.


VSIG1 Recommended name:

V-set and immunoglobulin domain containing 1 (VSIG1)

Aliases for VSIG1

GPA34,Glycoprotein A34,Cell surface A33 antigen

VSIG10 Recommended name:

V-set and immunoglobulin domain containing 10 (VSIG10)

Aliases for VSIG10

VSIG10

VSIG10L Recommended name:

V-set and immunoglobulin domain containing 10 like (VSIG10L)

Aliases for VSIG10L

VSIG10-like protein

VSIG2 Recommended name:

V-set and immunoglobulin domain containing 2 (VSIG2)

Aliases for VSIG2

CTH,CTXL,Cortical thymocyte-like protein,CT-like protein

VSIG4 Recommended name:

V-set and immunoglobulin domain containing 4 (VSIG4)

Aliases for VSIG4

CRIg,Z39IG,Protein Z39Ig

VSIG8 Recommended name:

V-set and immunoglobulin domain containing 8 (VSIG8)

Aliases for VSIG8

C1orf204

En la tabla siguiente se muestra una comparativa de todos los reactivos disponibles en nuestro catálogo (Primary Antibodies, ELISA Kits, Proteins and Peptides, CLIA Kits) relacionados con VSIG - V-set and immunoglobulin domain containing

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immunoassays

providerCodereferencenamereactivitysample typeassay typetest rangesensitivitypricesize 1uniprot idstatus
AbbexaVSIG1abx384260Human V-set and immunoglobulin domain-containing protein 1 (VSIG1) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.Sandwich0.156 ng/ml - 10 ng/ml< 0.094 ng/ml71596 testsQ86XK7RUO
AbbexaVSIG10abx553207Human V-set and immunoglobulin domain-containing protein 10 (VSIG10) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ8N0Z9RUO
AbbexaVSIG10Labx553205Human V-set and immunoglobulin domain-containing protein 10-like (VSIG10L) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ86VR7RUO
AbbexaVSIG2abx153491Human V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) ELISA KitHumanTissue homogenates and other biological fluids.Competitive493.83 pg/ml - 40000 pg/ml< 152.5 pg/ml71596 testsRUO
AbbexaVSIG2abx490539Human V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) CLIA KitHumanTissue homogenates and other biological fluids.Competitive493.83 pg/ml - 40000 pg/ml< 152.5 pg/ml84596 testsRUO
AbbexaVSIG4abx553216Human V-set and immunoglobulin domain-containing protein 4 (VSIG4) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.78 ng/ml - 50 ng/ml71596 testsQ9Y279RUO
AbbexaVSIG8abx553219Human V-set and immunoglobulin domain-containing protein 8 (VSIG8) ELISA KitHumanTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsP0DPA2RUO
AbbexaVSIG1abx553212Mouse V-set and immunoglobulin domain-containing protein 1 (VSIG1) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9D2J4RUO
AbbexaVSIG10abx553208Mouse V-set and immunoglobulin domain-containing protein 10 (VSIG10) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsD3YX43RUO
AbbexaVSIG10Labx553206Mouse V-set and immunoglobulin domain-containing protein 10-like (VSIG10L) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsD3YZF7RUO
AbbexaVSIG2abx553215Mouse V-set and immunoglobulin domain-containing protein 2 (VSIG2) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ9Z109RUO
AbbexaVSIG8abx553220Mouse V-set and immunoglobulin domain-containing protein 8 (VSIG8) ELISA KitMouseTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ6P3A4RUO
AbbexaVSIG1abx553213Rat V-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1) ELISA KitRatTissue homogenates, cell lysates and other biological fluids.0.156 ng/ml - 10 ng/ml71596 testsQ4KLY3RUO

Primary Antibodies

providerCodereferencenamereactivityclonalityhostimmunogen targetisotypeconjugationtested applicationspricesize 1uniprot idstatus
FineTestVSIG1FNab09454anti- VSIG1 antibodyhumanpolyclonalRabbitV-set and immunoglobulin domain containing 1IgGUnconjugatedELISA, WB, IHC100µgQ86XK7RUO
FineTestVSIG1FNab10744anti- VSIG1 antibodyhumanpolyclonalRabbitV-set and immunoglobulin domain containing 1IgGUnconjugatedELISA, WB100µgQ86XK7RUO
AbbexaVSIG1abx026506V-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1)IgGUnconjugatedELISA, WB, IHC292.580 µlQ86XK7RUO
AbbexaVSIG1abx239454V-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1)IgGUnconjugatedELISA, WB, IHC364100 µgQ86XK7RUO
AbbexaVSIG1abx240197V-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1)IgGUnconjugatedELISA, WB364100 µgQ86XK7RUO
AbbexaVSIG10abx210745VSIG10 AntibodyHumanPolyclonalRabbitVSIG10IgGUnconjugatedELISA, IHC26050 µlQ8N0Z9RUO
AbbexaVSIG10abx210312VSIG10 AntibodyHumanPolyclonalRabbitVSIG10IgGUnconjugatedELISA, IHC26050 µlQ8N0Z9RUO
AbbexaVSIG2abx309368V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) Antibody (HRP)HumanPolyclonalRabbitV-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2)IgGHRPELISA16920 µgQ96IQ7RUO
AbbexaVSIG2abx037978V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2)IgGUnconjugatedELISA, WB, IHC357.5100 µgRUO
AbbexaVSIG2abx309370V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) Antibody (Biotin)HumanPolyclonalRabbitV-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2)IgGBiotinELISA16920 µgQ96IQ7RUO
AbbexaVSIG2abx309369V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) Antibody (FITC)HumanPolyclonalRabbitV-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2)IgGFITC16920 µgQ96IQ7RUO
AbbexaVSIG2abx301548V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2)IgGUnconjugatedELISA, IHC16920 µgQ96IQ7RUO
AbbexaVSIG4abx376038V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)UnconjugatedELISA, WB351100 µgQ9Y279RUO
AbbexaVSIG4abx316698V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody (FITC)HumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGFITC16920 µgQ9Y279RUO
AbbexaVSIG4abx316699V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody (Biotin)HumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGBiotinELISA16920 µgQ9Y279RUO
AbbexaVSIG4abx421759V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanMonoclonalMouseV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)VHH-mFcUnconjugatedELISA, FCM31250 µgQ9Y279RUO
AbbexaVSIG4abx316697V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) Antibody (HRP)HumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGHRPELISA16920 µgQ9Y279RUO
AbbexaVSIG4abx461635V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanMonoclonalCHO cellsV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)VHH-8His-Cys-tagUnconjugatedELISA442100 µgQ9Y279RUO
AbbexaVSIG4abx402457V-set and immunoglobulin domain-containing protein 4 (VSIG4) AntibodyHumanMonoclonalHumanV-set and immunoglobulin domain-containing protein 4 (VSIG4)IgG1UnconjugatedELISA29950 µlQ9Y279RUO
AbbexaVSIG4abx036350V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGUnconjugatedELISA, WB357.5100 µgRUO
AbbexaVSIG4abx030625V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGUnconjugatedELISA, WB292.580 µlQ9Y279RUO
AbbexaVSIG4abx461881V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanMonoclonalV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)VHH-8His-Cys-tagUnconjugatedELISA442100 µgQ9Y279RUO
AbbexaVSIG4abx421760V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanMonoclonalMouseV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgG2aUnconjugatedELISA, FCM31250 µgQ9Y279RUO
AbbexaVSIG4abx302332V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGUnconjugatedELISA, IHC, IF/ICC16920 µgQ9Y279RUO
AbbexaVSIG4abx240268V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4)IgGUnconjugatedELISA, WB364100 µgQ9Y279RUO
AbbexaVSIG8abx346503V-set and immunoglobulin domain-containing protein 8 (VSIG8) Antibody (FITC)HumanPolyclonalRabbitV-set and immunoglobulin domain-containing protein 8 (VSIG8)IgGFITC16920 µgP0DPA2RUO
AbbexaVSIG8abx346502V-set and immunoglobulin domain-containing protein 8 (VSIG8) Antibody (HRP)HumanPolyclonalRabbitV-set and immunoglobulin domain-containing protein 8 (VSIG8)IgGHRPELISA16920 µgP0DPA2RUO
AbbexaVSIG8abx346504V-set and immunoglobulin domain-containing protein 8 (VSIG8) Antibody (Biotin)HumanPolyclonalRabbitV-set and immunoglobulin domain-containing protein 8 (VSIG8)IgGBiotinELISA16920 µgP0DPA2RUO
AbbexaVSIG8abx346501V-set and immunoglobulin domain-containing protein 8 (VSIG8) AntibodyHumanPolyclonalRabbitV-set and immunoglobulin domain-containing protein 8 (VSIG8)IgGUnconjugatedELISA, IHC, IF/ICC16920 µgP0DPA2RUO
AbbexaVSIG8abx212716VSIG8 AntibodyHumanPolyclonalRabbitVSIG8IgGUnconjugatedELISA, IHC26050 µlQ5VU13RUO
AbbexaVSIG8abx211811VSIG8 AntibodyHumanPolyclonalRabbitVSIG8IgGUnconjugatedELISA, WB, IHC26050 µlQ5VU13RUO
AbbexaVSIG8abx026457V-Set And Immunoglobulin Domain-Containing Protein 8 (VSIG8) AntibodyHumanPolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 8 (VSIG8)IgGUnconjugatedELISA, WB, IHC292.580 µlQ5VU13RUO
AbbexaVSIG1abx457038V-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1) AntibodyMousePolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 1 (VSIG1)IgGUnconjugatedELISA, WB, IHC26050 µgQ9D2J4RUO
AbbexaVSIG2abx457592V-Set And Immunoglobulin Domain-Containing Protein 2 (VSIG2) AntibodyMousePolyclonalRabbitV-Set And Immunoglobulin Domain-Containing Protein 2 (VSIG2)IgGUnconjugatedELISA, WB, IHC26050 µgQ9Z109RUO
AbbexaVSIG4abx376670V-Set And Immunoglobulin Domain Containing 4 (VSIG4) AntibodyMousePolyclonalRabbitV-Set And Immunoglobulin Domain Containing 4 (VSIG4)IgGUnconjugatedELISA, WB, IHC26050 µgF6TUL9RUO
AbbexaVSIG8abx025492V-Set And Immunoglobulin Domain-Containing Protein 8 (VSIG8) AntibodyMouseMonoclonalMouseV-Set And Immunoglobulin Domain-Containing Protein 8 (VSIG8)IgMUnconjugatedELISA, WB559100 µlP0DPA2RUO

Proteins and Peptides

providerCodereferencenameoriginexpressionhostconjugationtested applicationspricesize 1uniprot idstatus
AbbexaVSIG2abx655505Human V-Set And Immunoglobulin Domain Containing Protein 2 (VSIG2) ProteinHumanRecombinantE. coliUnconjugatedWB, SDS-PAGE18721 mgRUO
AbbexaVSIG4abx620638Human V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinHumanRecombinantMammalian cellsELISA, WB, SDS-PAGE546100 µgQ9Y279
AbbexaVSIG4abx690758Human V-Set And Immunoglobulin Domain Containing 4 (VSIG4) ProteinHumanRecombinantHumanSDS-PAGE24710 µgQ9Y279-1RUO
AbbexaVSIG4abx690774Mouse V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinMouseRecombinantHumanSDS-PAGE24710 µgRUO
AbbexaVSIG4abx691069Human V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinHumanRecombinantHEK293 cellsSDS-PAGE1079100 µgO75144-1RUO
AbbexaVSIG4abx692581Human V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinHumanRecombinantHEK293 cellsSDS-PAGE50750 µgQ9Y279-1RUO
AbbexaVSIG4abx692164Mouse V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinMouseRecombinantHEK293 cellsSDS-PAGE1079100 µgRUO
AbbexaVSIG4abx691315Human V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinHumanRecombinantHumanSDS-PAGE24710 µgQ9Y279RUO
AbbexaVSIG4abx692736Mouse V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinMouseRecombinantHEK293 cellsSDS-PAGE1079100 µgRUO
AbbexaVSIG4abx620639Human V-Set And Immunoglobulin Domain-Containing Protein 4 (VSIG4) ProteinHumanRecombinantMammalian cellsELISA, WB, SDS-PAGE546100 µgQ9Y279
AbbexaVSIG8abx690816Mouse V-Set and Ig Domain-Containing Protein 8 (VSIG8) ProteinMouseRecombinantHumanSDS-PAGE39010 µgQ6P3A4RUO
AbbexaVSIG8abx691222Human V-Set and Ig Domain-Containing Protein 8 (VSIG8) ProteinHumanRecombinantHumanSDS-PAGE27310 µgQ5VU13RUO
AbbexaVSIG8abx690559Human V-Set and Ig Domain-Containing Protein 8 (VSIG8) ProteinHumanRecombinantHumanSDS-PAGE27310 µgP0DPA2RUO

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